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Prevention of Ionizing Radiation-Induced Liver Microcirculation Changes by the Use of Flow Improvers

  • H. I. Bicher
  • L. D’Agostino
  • L. L. Doss
  • N. Kaufman
  • J. Amigone
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 92)

Abstract

Ionizing radiation causes destruction of mammalian tissue by two mechanisms (Kinzie et al, 1972): (1) inhibition of the proliferative capacity of rapidly dividing cells, and (2) irreversible damage to elements of the microcirculatory system. Organs such as liver, kidney and brain, not characterized by rapidly proliferating cells, exhibit a relatively pronounced radio-sensitivity in spite of a very slow rate of cellular turnover. The radiosensitivity of the microcirculation could provide the reason for the radiosensitivity of the entire organ or tissue.

Keywords

Platelet Aggregation Platelet Adhesiveness Microcirculation Disturbance Microcirculation Change Flow Improver 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Bicher, H.I. Prevention of sludge induced myocardial damage by an anti-adhesive drug. Bibl. Anat., 10: 202, 1969.PubMedGoogle Scholar
  2. 2.
    Bicher, H.I. Anti-adhesive drugs in thrombosis. Throm. et Diath. Haem., Suppl. 42: 197, 1970.Google Scholar
  3. 3.
    Bicher, H.I. Brain oxygen autoregulation: A protective reflex to hypoxia. Microvasc. Res. 8: 291–313, 1974.PubMedCrossRefGoogle Scholar
  4. 4.
    Bicher, H.I., Beemer, A.M. Induction of ischemic myocardial damage by red cell aggregation (sludge) in the rabbit. J. Atherosclerosis Res., 7: 409, 1967.CrossRefGoogle Scholar
  5. 5.
    Bicher, H.I., Beemer, A.M. Prevention by an anti-adhesive drug of thrombosis caused by blood cell aggregation. Angiol., 21: 413, 1970.CrossRefGoogle Scholar
  6. 6.
    Bicher, H.I., Dalrymple, G.V., Ashbrook, D., Smith, R., Harris, D. Effect of ionizing radiation on liver microcirculation oxygenation. 2nd International Conference for Society of Oxygen Transport to Tissue, 1976.Google Scholar
  7. 7.
    Bicher, H.I., Bruley, D.F., Reneau, D.D., Knisely, M.H. Effect of microcirculation changes on brain tissue oxygenation. J. Physiol. 217: 689–707, 1971.PubMedGoogle Scholar
  8. 8.
    Bicher, H.I., Marvin, P., Hunt, D.H., Bruley, D.F. Autonomic and pharmacological control of oxygen autoregulation mechanisms in brain tissue. ISOTT Symposium, Mainz, Germany, 1975. (To be published by Plenum Press, New York).Google Scholar
  9. 9.
    Born, G.V. Quantitative investigations into aggregation of blood platelets. J. Physiol. 162: 67, 1962.Google Scholar
  10. 10.
    Ingold, J., Reed, G., Kaplan, M.D. Am. J. Roentgenology 93: 200, 1965.Google Scholar
  11. 11.
    Kinzie, J., Studer, R.K., Perez, B., Potcher, E.J. Noncytokinetic radiation injury; anticoagulants as radioprotective agents in experimental radiation hepatitis. Science 175: 1481, 1972.PubMedCrossRefGoogle Scholar
  12. 12.
    Rubin, P. The radiographic expression of radiotherapeutic injury. An overview. Seminars in Roentgenology 1: 5, 1974.CrossRefGoogle Scholar
  13. 13.
    Silver, I.A. A simple microelectrode for measuring p02 in gas or fluid. Med. Electron. Biol. Eng. 1: 547, 1963.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • H. I. Bicher
    • 1
  • L. D’Agostino
    • 1
  • L. L. Doss
    • 2
  • N. Kaufman
    • 1
  • J. Amigone
    • 1
  1. 1.Department of Radiation MedicineRoswell Park Memorial InstituteBuffaloUSA
  2. 2.Ellis Fischel Hospital ColumbiaUSA

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