Prevention of Ionizing Radiation-Induced Liver Microcirculation Changes by the Use of Flow Improvers

  • H. I. Bicher
  • L. D’Agostino
  • L. L. Doss
  • N. Kaufman
  • J. Amigone
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 92)


Ionizing radiation causes destruction of mammalian tissue by two mechanisms (Kinzie et al, 1972): (1) inhibition of the proliferative capacity of rapidly dividing cells, and (2) irreversible damage to elements of the microcirculatory system. Organs such as liver, kidney and brain, not characterized by rapidly proliferating cells, exhibit a relatively pronounced radio-sensitivity in spite of a very slow rate of cellular turnover. The radiosensitivity of the microcirculation could provide the reason for the radiosensitivity of the entire organ or tissue.


Platelet Aggregation Platelet Adhesiveness Microcirculation Disturbance Microcirculation Change Flow Improver 
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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • H. I. Bicher
    • 1
  • L. D’Agostino
    • 1
  • L. L. Doss
    • 2
  • N. Kaufman
    • 1
  • J. Amigone
    • 1
  1. 1.Department of Radiation MedicineRoswell Park Memorial InstituteBuffaloUSA
  2. 2.Ellis Fischel Hospital ColumbiaUSA

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