Advertisement

Oxygen Levels in Tumors in C3H Mice During Hyperthermia: Initial Data

  • H. W. Puffer
  • B. R. Wilson
  • N. E. Warner
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 92)

Abstract

Induction of tumor regression by hyperthermia has been reported since the late 19th century (Coley, 1893, Warren, 1935, Crile, 1962, and Pettigrew, 1975). These reports have generated renewed interest in the application of hyperthermia to cancer therapy. There seems little doubt that hyperthermia can increase damage to malignant cells without inducing unacceptable damage to normal tissue. However, the mechanism by which hyperthermia achieves these results remains unknown. It is known that oxygen levels in tumor tissue differs from that in normal tissue (Puffer, et al., 1976, and Vaupel, 1977). This study was undertaken to demonstrate whether changes in oxygen level occured in experimental mammary tumors in C3H mice during hyperthermia.

Keywords

Oxygen Level Travel Award Newed Interest Increase Oxygen Level Body Immersion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Coley, W.B. The treatment of malignant tumors by repeated innoculations of erysipelas: with a report of 10 original cases. Am. J. Med. Sci. 105: 487–511 (1893).CrossRefGoogle Scholar
  2. Crile, G. Selective destruction of cancers after exposure to heat. Annals of Surg. 156: 404–407 (1962).CrossRefGoogle Scholar
  3. Pettigrew, R.T. Cancer therapy by whole body heating. International Symposium on Hyperthermia and Radiation, Washington, D.C., April 28–30 (1975).Google Scholar
  4. Puffer, H.W., Warner, N.E., Schaeffer, L.D., Wetts, R.W., and Bradbury, M. Preliminary observations of oxygen levels in microcirculation of tumors in C3H mice in: Oxygen transport to tissue — II Eds. Grote, Reneau, and Thews, Adv. in Exp. Med. Biol. 75: 605–610 (1976).Google Scholar
  5. Puffer, H.W., and Warner, N.E. Response of the microvasculature in experimental mammary tumors in C3H mice to selected vasoactive drugs. Proc. West. Pharmacol. Soc. 18: 133–135 (1975).PubMedGoogle Scholar
  6. Vaupel, P. Hypoxia in neoplastic tissue. Microvascular Research. 13: 399–408 (1977).PubMedCrossRefGoogle Scholar
  7. Warren, S.L. Preliminary study of the effect of artificial fever upon hopeless tumor cases. Am. J. Roentgenology. 33; 75–87 (1935).Google Scholar

Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • H. W. Puffer
    • 1
  • B. R. Wilson
    • 1
  • N. E. Warner
    • 1
  1. 1.Department of Pathology, School of MedicineUniversity of Southern CaliforniaLos AngelesUSA

Personalised recommendations