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Intracapillary HbO2 Saturation in Tumor Tissue of DS-Carcinosarcoma During Normoxia

  • P. Vaupel
  • W. A. Grunewald
  • R. Manz
  • W. Sowa
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 92)

Abstract

Investigations on solid tumor tissue have shown that O2 uptake by cancer cells depends largely on the supply conditions. The absence of sufficient neovascularization and a general rarefaction of the terminal vascular bed during tumor growth as well as reduced and inhcmogeneous blood flew due to vascular stasis in neoplastic tissue prevent normal functions of the terminal vascular bed. In some areas of the tumor circulating blood is not visible despite the intactness of vessels. Stasis occurs since lacuna-like, sinusoidal and cystiform blood vessels cannot be drained completely because ‘tissue-pressure’ due to continuous cell proliferation can prevent efficient circulation. Thrombosis follows and results in the occlusion of the vessels (Vaupel 1977). In addition, a considerable portion of tumor blood crosses arterio-venous shunts instead of circulating through the vascular network. Furthermore, the acidic environment in tumors may reduce red cell deformability during tumor passage.

Keywords

Neoplastic Tissue Solid Tumor Tissue Tumor Passage Tumor Capillary Vascular Stasis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. BORK, R., VAUPEL, P., THEWS, G. : Atemgas-pH-Nonogramme für das Rattenblut bei 37° C. Anaesthesist 24, 84 – 90 (1975)PubMedGoogle Scholar
  2. GRUNEWALD, W. A., LübBERS, D. W. : Die Bestimmung der intracapillären HbO2-Sättigung mit einer kryo-mikrophotometrischen Methode angewandt am Myokard des Kaninchens. Pflügers Arch. 353, 255 – 273 (1975)PubMedCrossRefGoogle Scholar
  3. GRUNEWALD, W. A., LUBBERS, D. W. : Cryomicrophotometry: A method for analyzing the intracapillary HbO2 saturation of organs under different O2 supply conditions, In: Oxygen transport to tissue — II. Eds.: Grote, J., Reneau, D., Thews, G. ; New York, London: Plenum Press 1976Google Scholar
  4. GRUNEWALD, W. A., SOWA, W. : Capillary structures and O2 supply to tissue. Rev. Physiol. Biochem. Pharmacol. 77, 149 – 209 (1977)PubMedCrossRefGoogle Scholar
  5. GULLINO, P. M., GRANTHAM, F. H. : Studies on the exchange of fluids between host and tumor. I. A method for growing “tissue -isolated” tumors in laboratory animals. J. Nat. Cancer Inst. 27, 679 – 693 (1961)PubMedGoogle Scholar
  6. LüBBERS, D. W., WODICK, R.: The examination of multicomponent systems in biological materials by means of a rapid scanning photometer. Appl. Optics 8, 1055 – 1062 (1969)CrossRefGoogle Scholar
  7. VAUPEL, P.: Atemgaswechsel und Glucosestoffwechsel von Implantationstumoren (DS-Carcinosarkcm) in vivo. Wiesbaden: Steiner 1974Google Scholar
  8. VAUPEL, P.: Hypoxia in neoplastic tissue. Microvasc. Res. 13, 399 – 408 (1977)PubMedCrossRefGoogle Scholar
  9. VAUPEL, P., GüNTHER, H., GROTE, J., AUMüLLER, G. : Atemgaswechsel und Glucosestoffwechsel von Tumoren (DS-Carcinosarkcm) in vivo. I. Experimentelle Untersuchungen der versorgungsbestimmenden Parameter. Z. ges. exp. Med. 156, 283 – 294 (1971)CrossRefGoogle Scholar
  10. VAUPEL, P., THEWS, G., WENDLING, P.: Kritische Sauerstoff- und Glucoseversorgung maligner Tumoren. Dtsch. med. Wschr. 101, 1810 – 1816 (1976)PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • P. Vaupel
    • 1
  • W. A. Grunewald
    • 2
  • R. Manz
    • 2
  • W. Sowa
    • 2
  1. 1.Institute of PhysiologyUniversity of MainzGermany
  2. 2.Institute of PhysiologyUniversity of RegensburgGermany

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