Study of Tissue Oxygen Gradients by Single and Multiple Indicators

  • Britton Chance
  • Bjørn Quistorff
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 92)


There are two types of naturally occurring oxygen indicators. The first includes myoglobin and some soluble enzyme systems and may be uniformly distributed in low concentration over the cytosol: the second is localized and concentrated either in discrete organelles about a micron in diameter such as the mitochondria or the peroxisomes (W.eibel 1969), or in more extended organelles such as the endoplasmic reticulum (Claude et al. 1947). In both cases, differing resolutions and sensitivities are possible.


H202 Generation Ischemic Area Pyridine Nucleotide Oxygen Gradient Glycollate Oxidase 
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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • Britton Chance
    • 1
  • Bjørn Quistorff
    • 1
    • 2
  1. 1.Johnson Research Foundation, School of MedicineUniversity of PennsylvaniaPhiladelphiaUSA
  2. 2.Department of Biochemistry AUniversity of PennsylvaniaCopenhagenDenmark

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