Density Dependent Energy Changes and Adaptive Growth in Populations of Mouse Fibroblasts in Vitro

  • R. J. Werrlein
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 92)


When a tissue is damaged due to pathological stress or wounding, recovery depends on the homeostatic mechanisms of the constituent cells to repair the damage and restore environmental constancy. This infers that the integration of regulatory metabolism is activated and maintained through environmental feedback and requires that populations of cells respond as a highly coordinated unit. Adenine nucleotides and oxygen have been suggested as regulatory parameters of metabolism (Atkinson, 1968; Holian et al, 1977; Wilson et al, 1977a). On the strength of these suggestions their combined energetics and homeostatic control over cell proliferation and population density was investigated using a mammalian cell culture system.


Respiratory Rate Adenine Nucleotide Increase Population Density Adaptive Growth Environmental Feedback 


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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • R. J. Werrlein
    • 1
  1. 1.Department of Pathology, The Medical SchoolUniversity of BristolBristolEngland

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