Regulation of Mitochondrial Respiration in Intact Tissues: A Mathematical Model
Adenosine triphosphate [ATP] synthesized by mitochondrial oxidative phosphorylation is utilized in most of the biosynthetic pathways of the cell as well as for maintenance of the intracellular ion balance and for specialized functions such as muscle contraction and nerve transmission. This central role in cellular metabolism requires that mitochondrial oxidative phosphorylation (respiration) be subject to precise regulation by the cell. Understanding of this regulatory mechanism both qualitatively and quantitatively is essential to our knowledge of cytosolic-mitochondrial interrelationships and of overall cellular metabolism.
KeywordsRespiratory Rate Mitochondrial Respiration Turnover Number Heart Mitochondrion Sodium Ascorbate
Unable to display preview. Download preview PDF.
- Chance, B., Erecinska, M. and Chance, E.M. (1973) Oxidase and Related Redox Systems II, (T.E. King, H.S. Mason and M. Morrison, eds.) Univ. Park Press, p. 851–866.Google Scholar
- George, P. (1965) in “Oxidases and Related Redox Sytems” (T.E. King, H.S. Mason and M. Morrison, eds.) Vol. 1, John Wiley, N.Y. p. 3–33.Google Scholar
- Greenwood, C., Wilson, M.T. and Brunori, M. (1974) Biochem. J. 137, 202–215.Google Scholar
- Wilson, D.F., Erecinska, M., Lindsay, J.G., Leigh, J.S.Jr. and Owen C.S. (1975) Proc. 10th FEBS Meeting, p. 195–210.Google Scholar
- Wilson, D.F., Owen, C.S. and Holian, A. (1977) Arch. Biochem. Biophys., August issue.Google Scholar