A Comparison of Two Nonclassical Models for Oxygen Consumption in Brain and Liver Tissue

  • Donald G. Buerk
  • Gerald M. Saidel
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 92)


Warburg-type experiments using tissue slices demonstrate non-classical chemical reaction kinetics [7]. Longmuir et al. [8] found that a Michaelis-Menten kinetic model more accurately. described experimental data from several different tissues. Brain tissue oxygen consumption was not significantly different from classical zero-order reaction kinetics, whereas liver tissue exhibited the most substantial deviation from the classical model. More recently, Buerk and Longmuir [2] have shown that oxygen consumption does not follow simple zero-order kinetics in either brain or liver tissue. The experimentally measured steady-state pO2 profiles from this study have been compared with nonclassical models for oxygen consumption.


Oxygen Consumption Liver Tissue Oxygen Consumption Rate Tissue Slice Mitochondrial Suspension 
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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • Donald G. Buerk
    • 1
  • Gerald M. Saidel
    • 2
  1. 1.Department of Chemical EngineeringNorthwestern UniversityEvanstonUSA
  2. 2.Department of Biomedical EngineeringCase Western Reserve UniversityClevelandUSA

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