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Dynamic Hypoxic Hypoxemia in Brain Tissue: Experimental and Theoretical Methodologies

  • William J. DorsonJr.
  • Beuford A. Bogue
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 92)

Abstract

An experimental system was assembled to study feline cerebral cortex cellular and extracellular pO2 response to rapid changes in carotid artery oxygen levels. The system has been described in prior articles in this series and elsewhere (Bogue and Dorson, 1973; Dorson and Bogue, 1973; Dorson and Bogue, 1976; Bogue, 1974). Changes in carotid artery oxygen level could be accomplished either by varying the ventilatory gas composition or by a carotid-jugular computer controlled exchange method. The latter technique involved cannulation of both internal carotid arteries and jugular veins. All other perfusion routes were supressed by compression. Relatively open flow was allowed in both directions with exchange between venous and arterial blood on an equal volume flow basis. This system resulted in the most rapid possible input change while maintaining close to normal physiological function. Many different types of changes were investigated, and this report will concentrate on oscillatory inputs caused by both the ventilation gas and blood exchange methods. No difference in response was noted up to the upper frequency limit of the ventilation method of 0.1 Hz while the exchange method was capable of 1.0 Hz oscillations.

Keywords

Brain Blood Flow Entire Test Period Oscillatory Waveform Interstitial Fluid Compartment Normalize Brain Blood 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Bogue, B.A. and Dorson, Jr., W.J. (1973) In ‘Oxygen Transport to Tissue: Pharmacology, Mathematical Studies, and Neonatology’ p.903 (eds. Bruley, D.F. and Bicher, H.I.). Plenum Publishing Corp., New York.Google Scholar
  2. Bogue, B.A. (1974) Feline Brain Tissue pO2 Response to Step and Oscillating Arterial pO2 Changes. Ph.D. Thesis, Arizona State University.Google Scholar
  3. Dorson, W.J. and Bogue, B.A. (1973) In ‘Oxygen Transport to Tissue: Instrumentation, Methods, and Physiology’ p.251 (eds. Bicher, H.I. and Bruley, D.F.). Plenum Publishing Corp., New York.Google Scholar
  4. Dorson, Jr., W.J. and Bogue, B.A. (1976) In ‘Oxygen Transport to Tissue-II’ p. 343 (eds. Grote, J., Reneau, D., and Thews, G.). Plenum Publishing Corp., New York.Google Scholar
  5. Leniger-Follert, E., Wrabetz, W., and Lübbers, D.W. (1976) In ‘Oxygen Transport to Tissue-II’ p.361 (eds. Grote, J., Reneau, D., and Thews, G.). Plenum Publishing Corp., New York.Google Scholar

Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • William J. DorsonJr.
    • 1
    • 2
  • Beuford A. Bogue
    • 1
    • 2
  1. 1.Department of Chemical and BioengineeringArizona State UniversityTempeUSA
  2. 2.HOSPAL Medical CorporationSalt Lake CityUSA

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