The Myoglobin Probed Optical Studies of Myocardial Energy Metabolism

  • M. Tamura
  • N. Oshino
  • B. Chance
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 92)

Abstract

The oxygen supply to the heart is one of the fundamental parameters of the heart function, since cardiac contraction is supported by ATP produced by combustion of substrates, mainly at the mitochondrial level. Cardiac muscle contains myoglobin in cytosol and cytochromes in mitochondria, both of which participate in the respiratory mechanisms of the heart. The present paper describes an optical approach to myocardial energy metabolism with the intention of detecting the absorption changes of myoglobin during a single contraction-relaxation cycle.

Keywords

Combustion Hydrolysis Titration Respiration Bicarbonate 

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References

  1. Chance, B. and Graham, N. (1971) Rev. Sci. Inst. 42, 941.CrossRefGoogle Scholar
  2. Oshino, N., Sugano, T., Oshino, R. and Chance, B. (1974) Biochem. Biophys. Acta. 368, 298.PubMedCrossRefGoogle Scholar
  3. Safer, B. and Williamson, J.R. (1973) J. Biol. Chem. 248, 2570.PubMedGoogle Scholar
  4. Tamura, M., Oshino, N., Chance, B. and Silver, I. Biochem. J. (in press)Google Scholar

Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • M. Tamura
    • 1
    • 2
  • N. Oshino
    • 1
    • 3
  • B. Chance
    • 1
  1. 1.Johnson Research Foundation, School of MedicineUniversity of PennsylvaniaPhiladelphiaUSA
  2. 2.The Institute of Scientific and Industrial ResearchOsaka UniversityOsakaJapan
  3. 3.Nihon Sherring, K.K.OsakaJapan

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