Kinetics of Changes in PO2 and Extracellular Potassium Activity in Stimulated Rat Sympathetic Ganglia

  • C. Friedli
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 92)


Increase in metabolic rate during electrical activity has been recorded in various nervous tissue preparations yet measurements of oxygen uptake by isolated tissues have so far suffered from important time lags (Larrabee, 1958; Lipton, 1973) and therefore have not permitted analysis of transients. This paper describes PO2 changes recorded within tissue with fast responding microelect-rodes. A perfused preparation with relatively simple geometry was chosen to facilitate the interpretation in terms of oxygen consumption per unit volume (Q).


Compound Action Potential Ceiling Level Point Source Model Stagnant Layer HEPES Solution 


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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • C. Friedli
    • 1
  1. 1.Department of Physiology, School of MedicineUniversity of GenevaSwitzerland

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