Kinetics of Changes in PO2 and Extracellular Potassium Activity in Stimulated Rat Sympathetic Ganglia

  • C. Friedli
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 92)


Increase in metabolic rate during electrical activity has been recorded in various nervous tissue preparations yet measurements of oxygen uptake by isolated tissues have so far suffered from important time lags (Larrabee, 1958; Lipton, 1973) and therefore have not permitted analysis of transients. This paper describes PO2 changes recorded within tissue with fast responding microelect-rodes. A perfused preparation with relatively simple geometry was chosen to facilitate the interpretation in terms of oxygen consumption per unit volume (Q).


Compound Action Potential Ceiling Level Point Source Model Stagnant Layer HEPES Solution 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Birks, R. and Macintosh, F.C. (1961) Can. J.Biochem.Physiol. 39, 787.CrossRefGoogle Scholar
  2. Brinley, F.J. (1967) J.Neurophysiol. 30, 1531.PubMedGoogle Scholar
  3. Brown, D.A. and Scholfield, C.N. (1974) J.Physiol. 242, 307.PubMedGoogle Scholar
  4. Carslaw, H.S. and Jaeger, J.C. (1959) Conduction of Heat. Oxford Univ. Press, London.Google Scholar
  5. Friedli, C. Thesis. Manuscript in preparation.Google Scholar
  6. Ganfield, R.A., Nair, P. and Whalen, W.J. (1970) Am.J.Physiol. 219, 814.PubMedGoogle Scholar
  7. Kriz, N., Sykova, E. and Vyklicky, L. (1975) J.Physiol., Lond., 249, 167.Google Scholar
  8. Krnjevic, K. and Morris, M.E. (1974) Can.J.Physiol.Pharmacol. 52, 852.PubMedCrossRefGoogle Scholar
  9. Larrabee, G. (1958) J.Neurochem. 2, 81.PubMedCrossRefGoogle Scholar
  10. Lipton, P. (1973) Biochem.J. 136, 999.PubMedGoogle Scholar
  11. Whalen, W.J., Riley, J. and Nair, P. (1967) J.appl.Physiol. 23, 798.PubMedGoogle Scholar
  12. Zeuthen, T., Hiam, R.C. and Silver, I.A. (1974) Adv.exp.Biol.Med. 50, 145.Google Scholar

Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • C. Friedli
    • 1
  1. 1.Department of Physiology, School of MedicineUniversity of GenevaSwitzerland

Personalised recommendations