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Sexual Differentiation and the Growth Process

  • J. Joe Ford
  • John Klindt

Abstract

As adults, males are larger than females in most species with which we are familiar, but this generalization is not appropriate for all species (Ralls, 1976). In cattle, sheep, and swine, testicular secretions (testosterone and its metabolites) are associated with the greater size of males, but few discussions of growth in domestic farm animals address the total impact of these steroids on developmental processes. The influence of testicular steroids on growth and muscling during pubertal development is well documented (Tucker and Merkel, 1987), but when steers are produced by castration shortly after birth, they are not exposed to testicular secretions during postnatal development. Why then do steers grow faster and larger than heifers? A second point that has perplexed animal scientists is the inconsistency among cattle, sheep, and swine relative to body growth after castration of young males. From Hammond’s Farm Animals (Hammond et al., 1971) we quote, ‘‘While (at equal body weight) the castrated male, in sheep or cattle, has a higher proportion of muscle and less fat than the female, in pigs the position is reversed.” Trenkle and Marple (1983) reiterated this point: “The inconsistent ranking of the barrow as compared with the steer and wether is not easily explained.” We also are unable to fully explain this issue but speculate that this may relate to the time when sexual differentiation of the growth process occurs.

Keywords

Growth Hormone Sexual Differentiation Prolactin Secretion Gonadal Steroid Body Growth 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Adkins-Regan, E. 1981. Early organizational effects of hormones: an evolutionary perspective. In: N. T. Adler (Ed.) Neuroendocrinology of Reproduction: Physiology and Behavior, pp 159–228. Plenum Press, New York.CrossRefGoogle Scholar
  2. Anfinson, M. S., S. L. Davis, E. Christian and D. O. Everson. 1975. Episodic secretion of growth hormone in steers and bulls: an analysis of frequency and magnitude of secretory spikes occurring in a 24 hour period. J. Anim. Sci., Proc. West. Sect. 26:175.Google Scholar
  3. Arbona, J. R., D. N. Marple, D. R. Mulvaney, J. L. Sartin, O. H. Rahe, T. J. Prince, D. L. Kuhlers and S. B. Jungst. 1986. Secretory patterns of growth hormone in swine selected for growth. J. Anim. Sci. 63 (Suppl. 1):228.Google Scholar
  4. Bartness, T. J. and G. N. Wade. 1984. Effects of interscapular brown adipose tissue denervation on body weight and energy metabolism in ovariectomized and estradiol-treated rats. Behav. Neurosci. 98:674.Google Scholar
  5. Beatty, W. W. 1973. Postneonatal testosterone treatment fails to alter hormonal regulation of body weight and food intake of female rats. Physiol. Behav. 10:627.Google Scholar
  6. Beatty, W. W. 1979. Gonadal hormones and sex differences in nonreproductive behaviors in rodents: organizational and activational influences. Horm. Behav. 12:112.Google Scholar
  7. Berende, P. L. M. and E. J. Ruitenberg. 1983. Modifying growth: an example of possibilities and limitations. In: L. Peel and D. E. Tribe (Ed.) Domestication, Conservation and Use of Animal Resources, pp 191–233. Elsevier, Amsterdam.Google Scholar
  8. Bereskin, B., C. E. Shelby and D. F. Cox. 1973. Some factors affecting pig survival. J. Anim. Sci. 36:821.Google Scholar
  9. Berg, R. T. and R. M. Butterfield. 1976. New Concepts of Cattle Growth. Sydney Univ. Press, Sydney.Google Scholar
  10. Bradfield, P. G. E. 1968. Sex differences in the growth of sheep. In: G. A. Lodge and G. E. Lamming (Ed.) Growth and Development of Mammals, pp 92–108. Plenum Press, New York.Google Scholar
  11. Brody, S. 1945. Bioenergetics and Growth with Special Reference to the Efficiency Complex in Domestic Animals. Reinhold Publ. Corp., New York.Google Scholar
  12. Buyse, J., E. Decuypere, P. J. Sharp, L. M. Huybrechts, E. R. Kühn and C. Whitehead. 1987. Effect of corticosterone on circulating concentrations of corticosterone, prolactin, thyroid hormones and somatomedin C and on fattening in broilers selected for high or low fat content. J. Endocrinol. 112:229.PubMedCrossRefGoogle Scholar
  13. Clarke, I. J. 1982. Prenatal sexual development. Oxford Rev. Reprod. Biol. 4:101.Google Scholar
  14. Davis, S. L., K. L. Hossner and D. L. Ohlson. 1984. Endocrine regulation of growth in ruminants. In: J. F. Roche and D. O’Callaghan (Ed.) Manipulation of Growth in Farm Animals, pp 151–178. Martinus Nijhoff Publ. The Hague.Google Scholar
  15. Davis, S. L., D. L. Ohlson, J. Klindt and M. S. Anfinson. 1977. Episodic growth hormone secretory patterns in sheep: relationship to gonadal steroid hormones. Amer. J. Physiol. 233:E519.Google Scholar
  16. Davis, S. L., D. L. Ohlson, J. Klindt and M. S. Anfinson. 1978. Episodic patterns of prolactin and thyrotropin secretion in rams and wethers: influence of testosterone and diethylstilbestrol. J. Anim. Sci. 46:1724.Google Scholar
  17. DeHaan, K. C., L. L. Berger, D. J. Kesler, F. K. McKeith, D. L. Thomas and T. G. Nash. 1987b. Effect of prenatal androgenization on lamb performance and carcass composition. J. Anim. Sci. 65 (Suppl. 1):85.Google Scholar
  18. DeHaan, K. C., L. L. Berger, D. J. Kesler, F. K. McKeith, D. B. Faulkner and G. F. Cmarik. 1987a. Effect of prenatal androgenization on performance of steers and heifers. J. Anim. Sci. 65 (Suppl. 1):242.Google Scholar
  19. D’Occhio, M. J. and J. J. Ford. 1988. Sexual differentiation and adult sexual behavior in cattle, sheep and swine: the role of gonadal hormones. In: J. M. A. Sitsen (Ed.) Handbook of Sexology. Vol. 6. pp. 209–230. Elsevier, Amsterdam.Google Scholar
  20. Edén, S. 1979. Age- and sex-related differences in episodic growth hormone secretion in the rat. Endocrinology 105:555.PubMedCrossRefGoogle Scholar
  21. Feder, H. H. 1981a. Hormonal actions on the sexual differentiation of the genitalia and the gonad-otropin-regulation systems. In: N. T. Adler (Ed.) Neuroendocrinology of Reproduction: Physiology and Behavior, pp 89–126. Plenum Press, New York.CrossRefGoogle Scholar
  22. Feder, H. H. 1981b. Perinatal hormones and their role in the development of sexually dimorphic behaviors. In: N. T. Adler (Ed.) Neuroendocrinology of Reproduction: Physiology and Behavior. pp 127–157. Plenum Press, New York.CrossRefGoogle Scholar
  23. Florini, J. R. 1985. Hormonal control of muscle cell growth. J. Anim. Sci. 61 (Suppl. 2):21.Google Scholar
  24. Forbes, J. M., P. M. Driver, W. B. Brown and C. G. Scanes. 1979. The effect of daylength on the growth of lambs: 2. Blood concentrations of growth hormone, prolactin, insulin and thyroxine, and the effect of feeding. Anim. Prod. 29:43.Google Scholar
  25. Ford, J. J. 1982. Testicular control of defeminization in male pigs. Biol. Reprod. 27:425.Google Scholar
  26. Ford, J. J. and R. K. Christenson. 1987. Influences of pre- and postnatal testosterone treatment on defeminization of sexual receptivity in pigs. Biol. Reprod. 36:581.Google Scholar
  27. Froesch, E. R., C. Schmid, I. Zangger. E. Schoenle, E. Eigenmann and J. Zapf. 1986. Effects of IGF/somatomedins on growth an J differentiation of muscle and bone. J. Anim. Sci. 63 (Suppl. 2):57.Google Scholar
  28. Fuller, M. F. 1981. Sex differences in the nutrition and growth of pigs. In: W. Haresign (Ed.) Recent Advances in Animal Nutrition—1980. pp 157–169. Butterworths, London.Google Scholar
  29. Goy, R. W. and B. S. McEwen. 1980. Sexual Differentiation of the Brain. MIT Press, Cambridge, MA.Google Scholar
  30. Gustafsson, J.-A., A. Mode, G. Norstedt, P. Eneroth and T. Hokfelt. 1983a. Central control of prolactin and estrogen receptors in rat liver—expression of a novel endocrine system, the hypothalamo-pituitary-liver axis. Annu. Rev. Pharmacol. Toxicol. 23:259.Google Scholar
  31. Gustafsson, J.-A., A. Mode, G. Norstedt and P. Skett. 1983b. Sex steroid induced changes in hepatic enzymes. Annu. Rev. Physiol. 45:51.Google Scholar
  32. Hammond, J., Jr., I. L. Mason and T. J. Robinson. 1971. Hammond’s Farm Animals (4th Ed.). Edward Arnold, London.Google Scholar
  33. Hammond, J. and G. N. Murray. 1937. The body proportions of different breeds of bacon pigs. J. Agrc. Sci. 27:394.Google Scholar
  34. Hansson, I., K. Lundström and B. Malmros. 1975. Effect of sex and weight on growth, feed efficiency and carcass characteristics of pigs. 2. Carcass characteristics of boars, barrows and gilts, slaughtered at four different weights. Swed. J. Agrc. Res. 5:69.Google Scholar
  35. Harvey, S., C. G. Scanes, A. Chadwick and N. J. Bolton. 1979. Growth hormone and prolactin secretion in growing domestic fowl: influence of sex and breed. Brit. Poult. Sci. 20:9.Google Scholar
  36. Hines, R. H. 1968. The interaction of restricted feed intake and sex on swine performance and carcass quality. Anim. Breed. Abstr. 36:267.Google Scholar
  37. Ho, K. Y., D. A. Leong, Y. N. Sinka, M. L. Johnson, W. S. Evans and M. O. Thorner. 1986. Sex-related differences in GH secretion in rat using reverse hemolytic plaque assay. Amer. J. Physiol. 250:E650.Google Scholar
  38. Hoeffler, J. P. and L. S. Frawley. 1986. Capacity of individual somatotropes to release growth hormone varies according to sex: analysis by reverse hemolytic plaque assay. Endocrinology 119:1037.PubMedCrossRefGoogle Scholar
  39. Hoshino, S., M. Wakita, M. Suzuki and K. Yamamoto. 1982. Changes in a somatomedin-like factor and immunoassayable growth hormone during growth of normal and dwarf pullets and cockerels. Poult. Sci. 61:777.PubMedGoogle Scholar
  40. Hubard Ocariz, J. L., A. Littlejohn and I. S. Robertson. 1970. A comparison of entire and ovar-iectomized beef heifers treated with ethylestrenol. J. Agrc. Sci. 74:349.Google Scholar
  41. Huybrechts, L. M., D. B. King, T. J. Lauterio, J. Marsh and C. G. Scanes. 1985. Plasma concentrations of somatomedin-C in hypophysectomized, dwarf and intact growing domestic fowl as determined by heterologous radioimmunoassay. J. Endocrinol. 104:233.PubMedCrossRefGoogle Scholar
  42. Jansson, J.-O., S. Edén and O. Isaksson. 1983. Sites of action of testosterone and estradiol on longitudinal bone growth. Amer. J. Physiol. 244:E135.Google Scholar
  43. Jansson, J.-O., S. Edén and O. Isaksson. 1985. Sexual dimorphism in the control of growth hormone secretion. Endocrine Rev. 6:128.CrossRefGoogle Scholar
  44. Jansson, J.-O. and L. A. Frohman. 1987a. Differential effects of neonatal and adult androgen exposure on the growth secretory pattern in male rats. Endocrinology 120:1551.PubMedCrossRefGoogle Scholar
  45. Jansson, J.-O. and L. A. Frohman. 1987b. Inhibitory effect of the ovaries on neonatal androgen imprinting of growth hormone secretion in female rats. Endocrinology 121:1417.PubMedCrossRefGoogle Scholar
  46. Jenkins, T. G., J. Klindt and J. J. Ford. 1987. Effect of alteration of sexual differentiation upon growth, feed efficiency and empty body composition. J. Anim. Sci. 65 (Suppl. 1):248.Google Scholar
  47. Jost, A. and S. Magre. 1984. Testicular development phases and dual hormonal control of sexual organogenesis. In: M. Serio, M. Mottas, M. Zanisi and L. Martini (Ed.) Sexual Differentiation: Basic and Clinical Aspects, pp 1–15. Raven Press, New York.Google Scholar
  48. Kay, M. and R. Houseman. 1975. The influence of sex on meat production. In: D. J. A. Cole and R. A. Lawrie (Ed.) Meat, pp 85–108. Butterworths, London.Google Scholar
  49. Keller, D. G., V. G. Smith, G. H. Coulter and G. J. King. 1979. Serum growth hormone concentrations in Hereford and Angus calves: effects of breed, sire, sex, age, age of dam, and diet. Can. J. Anim. Sci. 59:367.Google Scholar
  50. Klindt, J., T. G. Jenkins and J. J. Ford. 1987. Prenatal androgen exposure and growth and secretion of growth hormone and prolactin in ewes postweaning. Proc. Soc. Exp. Biol. Med. 185:201.Google Scholar
  51. Klindt, J., T. G. Jenkins and K. A. Leymaster. 1985. Relationships between some estimates of growth hormone and prolactin secretion and rates of accretion of constituents of body gain in rams. Anim. Prod. 41:103.Google Scholar
  52. Klindt, J. and R. R. Maurer. 1986. Reciprocal cross effects on growth hormone and prolactin secretion in cattle: influence of genotype and maternal environment. J. Anim. Sci. 62:1660.Google Scholar
  53. Koong, L. J., C. L. Ferrell and J. A. Nienaber. 1985. Assessment of interrelationships among levels of intake and production, organ size and fasting heat production in growing animals. J. Nutr. 115:1383.PubMedGoogle Scholar
  54. Lee, V. M., B. Szepesi and R. J. Hansen. 1986. Gender-linked differences in dietary induction of hepatic glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase and malic enzyme in the rat. J. Nutr. 116:1547.PubMedGoogle Scholar
  55. Leung, F. C., W. J. Styles, C. I. Rosenblum, M. S. Lilburn and J. A. Marsh. 1987. Diminished hepatic growth hormone receptor binding in sex-linked dwarf broiler and leghorn chickens. Proc. Soc. Exp. Biol. Med. 184:234.Google Scholar
  56. Lucier, G. W., C. L. Thompson, T. C. Sloop and R. C. Rumbaugh. 1984. Sexual differentiation of rat hepatic estrogen and androgen action. In: M. Serio, M. Motta, M. Zanisi and L. Martini (Ed.) Sexual Differentiation: Basic and Clinical Aspects, pp 209–222. Raven Press, New York.Google Scholar
  57. Millard, J. W., T. O. Fox, T. M. Badger and J. B. Martin. 1987. Gonadal steroid modulation of growth hormone secretory patterns in the rat. In: R. J. Robbins and S. Melmed (Ed.) Acromegaly: A Century of Scientific and Clinical Progress, pp 139–150. Plenum Press, New York.Google Scholar
  58. Mooradian, A. D., J. E. Morley and S. G. Korenman. 1987. Biological actions of androgens. Endocrine Rev. 8:1.CrossRefGoogle Scholar
  59. Muir, L. A., S. Wien, P. F. Duquette, E. L. Riches and E. H. Cordes. 1983. Effects of exogenous growth hormone and diethylstilbestrol on growth and carcass composition of growing lambs. J. Anim. Sci. 56:1315.Google Scholar
  60. Norstedt, G. and R. Palmiter. 1984. Secretory rhythm of growth hormone regulates sexual differentiation of mouse liver. Cell 36:805.PubMedCrossRefGoogle Scholar
  61. Noshiro, M. and M. Negishi. 1986. Pretranslational regulation of sex-dependent testosterone hydroxylases by growth hormone in mouse liver. J. Biol. Chem. 261:15923.Google Scholar
  62. Gillivray, A. de la Chapelle and L. G. Brown. 1987. The sex-determining region of the human Y chromosome encodes a finger protein. Cell 51:1091.PubMedCrossRefGoogle Scholar
  63. Parkes, A. S. and A. J. Marshall. 1960. The reproductive hormones in birds. In: A. S. Parkes (Ed.) Marshall’s Physiology of Reproduction. Vol. I, Part 2, pp 583–706. Longmans, Green and Co., New York.Google Scholar
  64. Perry, B. N., A. McCracken, B. J. A. Furr and H. J. H. MacFie. 1979. Separate roles of androgen and oestrogen in the manipulation of growth and efficiency of food utilization in female rats. J. Endocrinol. 81:35.PubMedCrossRefGoogle Scholar
  65. Preston, R. L. 1975. Biological responses to estrogen additives in meat producing cattle and lambs. J. Anim. Sci. 41:1414.Google Scholar
  66. Price, T. D. and J. N. Wiltbank. 1978. Dystocia in cattle: a review and implications. Theriogen-ology 9:195.CrossRefGoogle Scholar
  67. Putney, D. J., W. E. Beal and G. A. Good. 1984. The effect of prenatal androgen exposure on sexual differentiation and growth hormone secretion in female calves. 10th Int. Congr. Anim. Reprod. Artif. Insem. Vol. 11:5.Google Scholar
  68. Ralls, K. 1976. Mammals in which females are larger than males. Rev. Biol. 51:245.Google Scholar
  69. Ray, D. E., W. H. Hale and J. A. Marchello. 1969. Influence of season, sex and hormonal growth stimulants on feedlot performance of beef cattle. J. Anim. Sci. 29:490.Google Scholar
  70. Schanbacher, B. D., W. Wu, J. A. Nienaber and G. L. Hahn. 1985. Twenty-four-hour profiles of prolactin and testosterone in ram lambs exposed to skeleton photoperiods consisting of various light pulses. J. Reprod. Fertil. 73:37.Google Scholar
  71. Seideman, S. C., H. R. Cross, R. R. Oltjen and B. D. Schanbacher. 1982. Utilization of the intact male for red meat production: a review. J. Anim. Sci. 55:826.Google Scholar
  72. Short, R. V. 1974. Sexual differentiation of the brain of the sheep. In: M. G. Forest and J.Bertrand (ed.) The Sexual Endocrinology of the Perinatal Period, pp 121–142. INSERM, Paris.Google Scholar
  73. Sidwell, G. M. and L. R. Miller. 1971. Production in some pure breeds of sheep and their crosses. II. Birth weights and weaning weights of lambs. J. Anim. Sci. 32:1090.Google Scholar
  74. Simpson, M., W. Marx, H. Becks and H. M. Evans. 1944. Effect of testosterone propionate on the body weight and skeletal system of hypophysectomized rats: synergism with pituitary growth hormone. Endocrinology 35:309.CrossRefGoogle Scholar
  75. Simpson, E., P. Chandler, R. Hunt, H. Hogg, K. Tomonari and A. McLaren. 1986. H-Y status of X/X Sxr1 male mice: in vivo tests. Immunology 57:345.PubMedGoogle Scholar
  76. Slob, A. K. and J. J. van der Werff ten Bosch. 1975. Sex differences in body growth in the rat. Physiol. Behav. 14:353.Google Scholar
  77. Steinetz, B. G., T. Giannina, M. Butler and F. Popick. 1972. The role of growth hormone in the anabolic action of methandrostenolone. Endocrinology 90:1396.PubMedCrossRefGoogle Scholar
  78. Tarttelin, M. F., J. E. Shryne and R. A. Gorski. 1975. Patterns of body weight change in rats following neonatal hormone manipulation: a “critical period” for androgen-induced growth increases. Acta Endocrinol. 79:177.PubMedGoogle Scholar
  79. Trenkle, A. and D. N. Marple. 1983. Growth and development of meat animals. J. Anim. Sci. 57 (Suppl. 2):273.PubMedGoogle Scholar
  80. Tucker, H. A. and R. A. Merkel. 1987. Applications of hormones in the metabolic regulation of growth and lactation in ruminants. Fed. Proc. 46:300.Google Scholar
  81. Van Vliet, G., D. M. Styne, S. L. Kaplan and M. M. Grumbach. 1983. Hormone ontogeny in the ovine fetus. XVI. Plasma immunoreactive somatomedin C/insulin-like growth factor I in the fetal and neonatal lamb and in the pregnant ewe. Endocrinology 113:1716.PubMedCrossRefGoogle Scholar
  82. Wade, G. N. 1985. Actions of gonadal steroids on adipose tissue in rodents. In: J. Vague, P. Bjöntorp, B. Guy-Grand, M. Rebuffé-Scrive and P. Vague (Ed.) Metabolic Complications of Human Obesities, pp 105–114. Excerpta Medica, Amsterdam.Google Scholar
  83. Wallace, L. R. 1944. The influence of sex upon carcass quality and efficiency of food utilisation. Proc N. Z. Soc. Anim. Prod. 4:64.Google Scholar
  84. Walstra, P. 1980. Growth and Carcass Composition from Birth to Maturity in Relation to Feeding Level and Sex in Dutch Landrace Pigs. H. Veenman and B. V. Zonen, Wageningen.Google Scholar
  85. Wilson, P. N. 1952. Growth analysis of the domestic fowl. I. Effect of plane of nutrition and sex on live-weights and external measurements. J. Agr. Sci. 42:369.CrossRefGoogle Scholar
  86. Zinn, S. A., R. W. Purchas, L. T. Chapin, D. Petitclerc, R. A. Merkel, W. G. Bergen and H. A. Tucker. 1986. Effects of photoperiod on growth, carcass composition, prolactin, growth hormone and Cortisol in prepubertal and postpubertal Holstein heifers. J. Anim. Sci. 63:1804.Google Scholar

Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • J. Joe Ford
    • 1
  • John Klindt
    • 1
  1. 1.Agricultural Research Service, Roman L. Hruska U.S. Meat Animal Research Center, Clay CenterUnited States Department of AgricultureUSA

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