Energy Balance Regulation

  • Roy J. Martin
  • J. Lee Beverly
  • Gary E. Truett


Energy balance regulation is a complex process involving several controlling systems and is similar in complexity to the regulation of body temperature and blood glucose. In fact, some of the mechanisms for energy balance regulation overlap with these two systems. The hierarchy of the systems is based on the highest priority of the organism for survival. This chapter will focus on signals of energy balance status from peripheral sources as well as the role of the central nervous system in integration of these signals and active control of either food intake or metabolism (Fig. 1).


Food Intake Brown Adipose Tissue Compensatory Growth Lateral Hypothalamic Area Food Intake Regulation 
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  1. Allen, Y. S., T. E. Adrian, J. M. Allen, K. Tatemoto, T. J. Crow, S. R. Bloom, and J. M. Polak. 1983. Neuropeptide Y distribution in the rat brain. Science 221:877.PubMedCrossRefGoogle Scholar
  2. Anand, B. K. and J. R. Brobeck. 1951. Hypothalamic control of food intake in rats and cats. Yale J. Biol. Med. 24:123.PubMedGoogle Scholar
  3. Anderson, D. B., E. L. Veenhuisen, W. P. Waitt, R. E. Paxton and S. S. Young. 1987. The effect of dietary protein on nitrogen metabolism, growth performance and carcass composition for finishing pigs fed Ractopamine. Fed. Proc. 46:1021 (Abstr.).Google Scholar
  4. Anderson, G. H. 1979. Control of protein and energy intake: role of plasma amino acids and brain neurotransmitters. Can. J. Physiol. Pharmacol. 57:1043.PubMedCrossRefGoogle Scholar
  5. Anil, M. H. and J. M. Forbes, 1980. Effect of insulin and gastro-intestinal hormones on feeding and plasma insulin in sheep. Horm. Metab. Res. 12:407.CrossRefGoogle Scholar
  6. Aou, S., Y. Oomura, H. Nishino, A. Inokuchi and Y. Mizuno. 1983. Influence of catecholamines on reward related neuronal activity in monkey orbitofrontal cortex. Brain Res. 267:165.PubMedCrossRefGoogle Scholar
  7. Asplund, J. M., H. B. Hendrick and C. D. Haugebak. 1975. Performance, digestibility and 40K levels in lambs during compensation for feed restriction. J. Anim. Sci. 40:138.Google Scholar
  8. Baile, C. A. and M. A. Della-Ferra. 1981. Nature of hunger and satiety control systems in ruminants. J. Dairy Sci. 64:1140.PubMedCrossRefGoogle Scholar
  9. Baile, C.A. and M. Della-Ferra. 1984. Peptidergic control of food intake in food-producing animals. Fed. Proc. 43:2898.PubMedGoogle Scholar
  10. Baile, C A., and M. J. Forbes. 1974. Control of feed intake and regulation of energy balance in ruminants. Physiol. Rev. 54:160.PubMedCrossRefGoogle Scholar
  11. Baile, C A., C L. McLaughlin, F. C. Buonomo, T. J. Lauterio, L. Marson and M. A. Della-Ferra. 1987. Opioid peptides and the control of feeding in sheep. Fed. Proc. 46:173.PubMedGoogle Scholar
  12. Bailey, J. W. and D. B. Anderson. 1980. Rate of fat compensation and growth efficiency of lipectomized Sprague-Dawley rats. J. Nutr. 110:1785.PubMedGoogle Scholar
  13. Baldwin, R. L. and A. C. Bywater. 1984. Nutritional energetics of animals. Annu. Rev. Nutr. 4:101.PubMedCrossRefGoogle Scholar
  14. Ban, T. 1975. Fiber connections in the hypothalamus and some autonomic functions. Pharmacol. Biochem. Behav. 3 (Suppl. 1):3.PubMedGoogle Scholar
  15. Barbosa, M. C and R. H. Miglorini. 1982. Free fatty acid mobilization in rats following intracer-ebroventricular norepinephrine. Amer. J. Physiol. 242:E248.PubMedGoogle Scholar
  16. Baumgardt, B. R. and A. D. Peterson. 1971. Regulation of food intake in ruminants. 8. Caloric density of diets for young growing lambs. J. Anim. Sci. 54:1191.Google Scholar
  17. Bellinger, L. L., V. E. Mendel, F. E. Williams and T. W. Castonguay. 1984. The effect of liver denervation on meal patterns, body weight and body composition of rats. Physiol. Behav. 33:661.PubMedCrossRefGoogle Scholar
  18. Bernardis, L. L. and L. L. Bellinger. 1987. The dorsomedial hypothalamic nucleus revisited: 1986 update. Brain Res. Rev. 12:321.CrossRefGoogle Scholar
  19. Beverly, J. L. and R. J. Martin. 1987. Glucose contribution to GABA shunt activity in the rat ventral hypothalamus: comparison of hyperphagic models. Fed. Proc. 46:1482 (Abstr.).Google Scholar
  20. Blaxter, K. L. 1971. Methods of measuring the energy metabolism of animals and interpretation of results obtained. Fed. Proc. 30:1436.PubMedGoogle Scholar
  21. Booth, D. A. 1972. Postabsorptively induced suppression of appetite and the energostatic control of feeding. Physiol. Behav. 9:199.PubMedCrossRefGoogle Scholar
  22. Booth, D. A. and M. E. Pitts. 1968. The role of glucose in insulin-induced feeding and drinking. Physiol. Behav. 3:447.CrossRefGoogle Scholar
  23. Bray, B. A. 1984. Hypothalamic and genetic obesity: an appraisal of the autonomic hypothesis and the endocrine hypothesis. Int. J. Obesity 8 (suppl.): 119.Google Scholar
  24. Bray, G. A. and Y. Nishizawa. 1978. Ventromedial hypothalamus modulates fat mobilization during fasting. Nature 274:900.PubMedCrossRefGoogle Scholar
  25. Bueno, L., M. J. Fargeas and P. Julie. 1986. Effects of calcitonin and CGRP alone in or in combination of food intake and forestomach (reticulum) motility in sheep. Physiol. Behav. 36:907.PubMedCrossRefGoogle Scholar
  26. Campfield, L. A., P. Brandon and F. J. Smith. 1985. On-line continuous measurement of blood glucose and meal pattern in free-feeding rats: the role of glucose in meal initiation. Brain Res. Bull. 14:605.PubMedCrossRefGoogle Scholar
  27. Campfield, L. A. and F. J. Smith. 1985. Functional coupling between transient declines in blood glucose and feeding behavior: temporal relationships. Brain Res. Bull. 17:427.CrossRefGoogle Scholar
  28. Campfield, L. A. and F. J. Smith. 1987. Glucose dynamics during feeding predict frequency of ingestion. Fed. Proc. 46:1482.Google Scholar
  29. DeBoer, J. O., L. A. Roovers, J. M. A. van Raaij and J. G. Hautvast. 1986. Adaptation of energy metabolism of overweight women to low energy intake, studied with whole body calorimeters. Amer. J. Clin. Nutr. 44:585.Google Scholar
  30. Debons, A. F., I. Krimsky, H. J. Likuski, A. From and R. J. Cloutier. 1968. Gold thioglucose damage to the satiety center: inhibition in diabetes. Amer. J. Physiol. 214:652.PubMedGoogle Scholar
  31. Debons, A. F., L. D. Zurek, C. S. Tse and S. Abrahasen. 1986. Central nervous system control of hyperphagia in hypothalamic obesity: dependence on adrenal glucocorticoids. Endocrinology 118:1678.PubMedCrossRefGoogle Scholar
  32. Della-Ferra, M. A. and C. A. Baile. 1979. Cholecystokinin octapeptide: continuous picomole injections into the cerebral ventricles of sheep suppress feeding. Science 206:471.CrossRefGoogle Scholar
  33. Della-Ferra, M. A. and C. A. Baile. 1980. CCK octapeptide injected in CSF decreases meal size and daily food intake in sheep. Peptides (Fayetteville) 1:51.CrossRefGoogle Scholar
  34. Della-Ferra, M. A. and C. A. Baile. 1984. Control of food intake in sheep. J. Anim. Sci. 59:1362.Google Scholar
  35. Della-Ferra, M. A., C. A. Baile, B. S. Schneider and J. Grinker. 1981. Cholecystokinin antibody injected in cerebral ventricles stimulates feeding in sheep. Science 212:687.CrossRefGoogle Scholar
  36. Denbow, D. M. and R. D. Myers. 1982. Eating, drinking and temperature responses to intracere-broventricular cholecystokinin in the chick. Peptides (Fayetteville) 3:739.CrossRefGoogle Scholar
  37. Drewry, M. M. 1986. Developmental changes in response to overfeeding. M. S. Thesis. Univ. of Georgia, Athens.Google Scholar
  38. Egli, G., W. Langhans and E. Scharrer. 1986. Selective hepatic vagotomy does not prevent compensatory feeding in response to body weight changes J. Auton. Nerv. Syst. 15:45.PubMedCrossRefGoogle Scholar
  39. Engeset, R. M. and R. C. Ritter. 1980. Intracerebroventricular 2-DG causes feeding in the absence of other signs of glucoprivation. Brian Res. 202:229.Google Scholar
  40. Epstein, A. N., S. Nicolaidis and R. Miselis. 1975. The glucoprivic control of food intake and the glucostatic theory of feeding behavior. In: G. E. Magenson and F. R. Calarescu (Ed.) Neural Integration of Physiological Mechanisms and Behavior. p 148. Univ. of Toronto Press, Toronto.Google Scholar
  41. Even, P. and S. Nicolaidis. 1986. Short-term control of feeding: limitation of the glucostatic theory. Brain Res. Bull. 17:621.PubMedCrossRefGoogle Scholar
  42. Everitt, B. J., T. Hokfelt, L. Terenius, K. Tatemoto, V. Mutt and M. Goldstein. 1984. Differential co-existence of neuropeptide Y (NPY)-like immunoreactivity with catecholamines in the central nervous system of the rat. Neuroscience 11:443.PubMedCrossRefGoogle Scholar
  43. Flatt, W. P., P. W. Moe, A. W. Munson and T. Cooper. 1969. Energy utilization in high producing cows. Proceedings 4th Symposium on Energy Metabolism. European Assoc. Animal Production Publ., Warsaw, Poland. Oriel Press, Newcastle upon Tyne, England.Google Scholar
  44. Forbes, J. M. 1985. Similarities and differences between intake control mechanisms in pigs, chickens and ruminants. Proc. Nutr. Soc. 44:331.PubMedCrossRefGoogle Scholar
  45. Forbes, J. M. 1986. Review of theories of food intake control. In: The Voluntary Food Intake of Farm Animals. Butterworths, London, pp. 15–34.Google Scholar
  46. Fox, D. G., R. L. Preston, B. Senft and R. R. Johnson. 1974. Plasma growth hormone levels and thyroid secretion rates during compensatory growth in cattle. J. Anim. Sci. 38:437.PubMedGoogle Scholar
  47. Friedman, M. I. and J. Granneman. 1983. Food intake and peripheral factors after a recovery from insulin-induced hypoglycemia. Amer. J. Physiol. 244:R374.PubMedGoogle Scholar
  48. Friedman, M. and E. M. Strieker. 1976. The physiological psychology of hunger: a physiological perspective. Psychol. Rev. 83:409.PubMedCrossRefGoogle Scholar
  49. Friedman, M. I. and M. G. Tordoff. 1986. Fatty acid oxidation and glucose utilization interact to control food intake in rats. Amer. J. Physiol. 251:R840.PubMedGoogle Scholar
  50. Friedman, M. I., M. G. Tordoff and I. Ramirez. 1986. Integrated metabolic control of food intake. Brain Res. Bull. 17:855.PubMedCrossRefGoogle Scholar
  51. Girard, C. L., J. R. Seoane and J. J. Matte. 1985. Studies of the role of gamma-aminobutyric acid in the hypothalamic control of feed intake in sheep. Can. J. Physiol. Pharmacol. 63:1297.PubMedCrossRefGoogle Scholar
  52. Grandison, L. and A. Guidotti. 1977. Stimulation of food intake by muscimol and beta-endorphin. Neuropharmacology 16:533.PubMedCrossRefGoogle Scholar
  53. Harper, A. E., N. J. Benevenga and R. M. Wohlueter. 1970. Effects of ingestion of disproportionate amounts of amino acids. Physiol. Rev. 50:428.PubMedGoogle Scholar
  54. Harris, R. B. S., T. R. Kasser and R. J. Martin. 1986. Dynamics of recovery of body composition after overfeeding, food restriction or starvation of mature female rats. J. Nutr. 116:2536.PubMedGoogle Scholar
  55. Harris, R. B. S. and R. J. Martin. 1984a. Recovery of body weight from below “set point” in mature female rats. J. Nutr. 114:1143.PubMedGoogle Scholar
  56. Harris, R. B. S. and R. J. Martin. 1984b. Lipostatic theory of energy balance: concepts and signals. Nutr. Behav. 1:253.Google Scholar
  57. Harris, R. B. S. and R. J. Martin. 1986. Metabolic response to a specific lipid-depleting factor in parabiotic rats. Amer. J. Physiol. 250:R276.PubMedGoogle Scholar
  58. Hervey, G. R. 1959. The effects of lesions in the hypothalamus in parabiotic rats. J. Physiol. (London) 145:336.PubMedGoogle Scholar
  59. Himms-Hagen, J. 1985. Brown adipose tissue metabolism and thermogenesis. Rev. Nutr. 5:69.Google Scholar
  60. Hoebel, B. G. 1985. Brain neurotransmitters in food and drug reward. Amer. J. Clin. Nutr. 42:113.Google Scholar
  61. Houpt, T. R. 1974. Stimulation of food intake in ruminants by 2-deoxy-D-glucose and insulin. Amer. J. Physiol. 227:161.PubMedGoogle Scholar
  62. Houpt, K. A., T. R. Houpt, and W. G. Pond 1979. The pig as a model for the study of obesity and control of food intake: a review. Yale J. Biol. Med. 53:307.Google Scholar
  63. Houpt, T. R. 1984. Control of feeding in pigs. J. Anim. Sci. 59:1345.PubMedGoogle Scholar
  64. Houpt, T. R. 1985. The physiological determinants of meal size in pigs. Proc. Nutr. Soc. 44:323.PubMedCrossRefGoogle Scholar
  65. Illingworth, P. J., R. T. Jung, P. W. Howie, P. Leslie and T. E. Isles. 1986. Diminution in energy expenditure during lactation. Brit. Med. J. 292:437.CrossRefGoogle Scholar
  66. Imaki, T., T. Shibasaki, M. Hotta, A. Masuda, H. Demura, K. Shizume and N. Ling. 1985. The satiety effect of growth hormone-releasing factor in rats. Brain Res. 340:186.PubMedCrossRefGoogle Scholar
  67. Inoue, S., G. A. Bray and Y. S. Mullen. 1978. Transplantation of pancreatic B-cells prevents development of hypothalamic obesity in rats. Amer. J. Physiol. 235:E266.PubMedGoogle Scholar
  68. Jhanwar-Uniyal, M., C. R. Roland, and S. F. Leibowitz. 1986. Diurnal rhythm of alpha2-norad-renergic receptors in the paraventricular nucleus and other brian areas: relation to circulating corticosterone and feeding behavior. Life Sci. 38:473.PubMedCrossRefGoogle Scholar
  69. Kandel, E. R. and J. W. Schwartz. 1985. Hypothalamus and limbic system II: motivation. In: E. R. Kandel and J. W. Schwartz (Ed.) Principles of Neural Science (2nd Ed.). Elsevier, Amsterdam, pp 450–460.Google Scholar
  70. Kasser, T. R., R. B. S. Harris and R. J. Martin. 1985. Level of satiety: GABA and pentose shunt activities in three brain sites associated with feeding. Amer. J. Physiol. 248:R453.PubMedGoogle Scholar
  71. Kasser, T. R., R. J. Martin, J. H. Gahagan and P. J. Wangsness. 1981. Fasting plasma hormones and metabolites in feral and domestic newborn pigs. J. Anim. Sci. 53:420.PubMedGoogle Scholar
  72. Kennedy, G. C. 1953. The role of depot fat in the hypothalamic control of food intake in rats. Proc. R. Soc. London Ser. B 140:578.CrossRefGoogle Scholar
  73. Kennedy, G. C. 1957. The development with age of hypothalamic restraint upon appetite of the rat. J. Endocrinol. 16:9.PubMedCrossRefGoogle Scholar
  74. Knoll, J. 1985. Satietin, a blood-borne, highly selective and potent anorectic glycoprotein. Biomed. Biochim. Acta 44:317.PubMedGoogle Scholar
  75. Krahn, D. D., A. Gosnell, A. S. Levine and J. E. Morley. 1984. Effects of calcitonin gene-related peptide on food intake. Peptides 5:861.PubMedCrossRefGoogle Scholar
  76. Kralym, F. S. and G. P. Smith. 1978. Combined pregastric and gastric stimulation by food is sufficient for normal meal size. Physiol. Behav. 21:405.CrossRefGoogle Scholar
  77. Landsberg, L. and J. B. Young. 1984. The role of the sympathoadrenal system in modulating energy expenditure. Clin. Endocrinol. Metab. 13:475.PubMedCrossRefGoogle Scholar
  78. Langhans, W., G. Egli and E. Scharrer. 1985. Regulation of food intake by hepatic oxidative metabolism. Brain Res. Bull. 15:425.PubMedCrossRefGoogle Scholar
  79. Langhans, W. and E. Scharrer. 1987. Evidence for a vagally mediated satiety signal derived from hepatic fatty acid oxidation. J. Auton Nerv. Syst. 18:13.PubMedCrossRefGoogle Scholar
  80. Larson, K. A. and D. B. Anderson. 1978. The effects of lipectomy on remaining adipose tissue depots in the Sprague-Dawley rat. Growth 42:469.PubMedGoogle Scholar
  81. Leibowitz, S. F. 1970. Reciprocal hunger-regulating circuits involving alpha- and beta-adrenergic receptors located, respectively, in the ventromedial and lateral hypothalamus. Proc. Natl. Acad. Sci. USA 67:1063.PubMedCrossRefGoogle Scholar
  82. Leibowitz, S. F. 1978. Paraventricular nucleus: a primary site mediating adrenergic stimulation of feeding and drinking. Pharmacol. Biochem. Behav. 8:163.PubMedCrossRefGoogle Scholar
  83. Leibowitz, S. F. 1986a. Brain neurochemistry and eating behavior. In: E. Ferrari and F. Brambilla (Ed.) Disorders of Eating Behavior: A Psychoneuroendocrine Approach, pp. 65–72. Perga-mon Press, Elmsford, NY.Google Scholar
  84. Leibowitz, S. F. 1986b. Brain monoamines and peptides: role in the control of eating behavior. Fed. Proc. 46:1396.Google Scholar
  85. Leibowitz, S. F., C. R. Rowland, L. Hor and V. Squillary. 1984. Noradrenergic feeding elicited via the paraventricular nucleus is dependent upon circulating corticosterone. Physiol. Behav. 32:857.PubMedCrossRefGoogle Scholar
  86. Le Magnen, J. 1981. The metabolic basis of dual periodicity of feeding in rats. Behav. Brain Sci. 4:561.CrossRefGoogle Scholar
  87. Le Magnen, J. 1983. Body energy balance and food intake: a neuroendocrine regulatory mechanism. Physiol. Rev. 63:314.PubMedGoogle Scholar
  88. Le Magnen, J. 1985. Hunger. Cambridge Univ. Press, London.Google Scholar
  89. Lepkovsky, S., M. K. Demick, F. Furuta, N. Snapir, R. Park, N. Narita and K. Komatsu. 1967. Response of blood glucose and plasma free fatty acids to fasting and injection of insulin and testosterone in chickens. Endocrinology 81:1001.PubMedCrossRefGoogle Scholar
  90. Leung, P. M. B. and Q. R. Rogers. 1969. Food intake: regulation by plasma amino acid pattern. Life Sci. 8:1.PubMedCrossRefGoogle Scholar
  91. Levine, A. S. and J. E. Morley. 1981. Reduction in feeding in rats by calcitonin. Brain Res. 222:187.PubMedCrossRefGoogle Scholar
  92. Levine, A. S. and J. E. Morley. 1984. Neuropeptide Y: a potent inducer of consummatory behavior in rats. Peptides 5:1025.PubMedCrossRefGoogle Scholar
  93. Lichtenstein, S. S., C. Marinescu and S. F. Leibowitz. 1984. Chronic infusion of norepinephrine and Clonidine into the hypothalamic paraventricular nucleus. Brain Res. Bull. 13:591.PubMedCrossRefGoogle Scholar
  94. Lorden, J. F., R. Dawson and M. Callahan. 1979. Effect of gold thioglucose lesions on central catecholamine levels in the mouse. Pharmacol. Biochem. Behav. 10:165.PubMedCrossRefGoogle Scholar
  95. Louis-Sylvestre, J. and J. Le Magnen. 1980. A fall in blood glucose precedes meal onset in free feeding rats. Neurosci. Biobehav. Res. 4 (Suppl. 1): 13.CrossRefGoogle Scholar
  96. McBride, B.W. and L. P. Milligan. 1985. Influence of feed intake and starvation on the magnitude of Na K-ATPase dependent respiration in duodenal mucosa of sheep. Brit. J. Nutr. 53:605.PubMedCrossRefGoogle Scholar
  97. McCaleb, M. L. and R. D. Myers. 1982. 2-Deoxy-D-glucose and insulin modify release of norepinephrine from rat hypothalamus. Amer. J. Physiol. 242:R596.PubMedGoogle Scholar
  98. McCaleb, M. L., R. D. Myers, G. Singer and G. Willis. 1979. Hypothalamic norepinephrine in the rat during feeding and push-pull perfusion with glucose, 2-DG, or insulin. Amer. J. Physiol. 236:R313.Google Scholar
  99. McHugh, P. R. and T. H. Muran. 1978. The accuracy of the regulation of caloric ingestion in the rhesus monkey. Amer. J. Physiol. 235:R29.PubMedGoogle Scholar
  100. McHugh, P. R. and T. H. Muran. 1979. Calories and gastric emptying: a regulatory capacity with implications for feeding. Amer. J. Physiol. 236:R254.Google Scholar
  101. Marks-Kaufman, R. 1982. Increased fat consumption induced by morphine administration in rats. Pharmacol. Biochem. Behav. 16:949.PubMedCrossRefGoogle Scholar
  102. Marshall, N. B. and J. Mayer. 1954. Energy balance in gold thioglucose obesity. Amer. J. Physiol. 178:271.PubMedGoogle Scholar
  103. Martin, R. J. and P. Lamprey. 1974. Changes in liver and adipose tissue enzymes and lipogenic activities during the onset of hypothalamic obesity in mice. Life Sci. 14:1121.PubMedCrossRefGoogle Scholar
  104. Maurice, D. V., J. E. Whisenhunt, J. E. Jones and K. D. Smoak. 1983. Effect of lipectomy on control of feed intake and homeostasis of adipose tissue in chickens. Poult. Sci. 62:1466.Google Scholar
  105. Mayer, J. 1953. Glucostatic mechanism of regulation of food intake. N. Engl. J. Med. 249:13.PubMedCrossRefGoogle Scholar
  106. Meier, A. H. and D. D. Martin. 1971. Temporal synergism of corticosterone and proclactin controlling fat storage in white throated sparrow, Zonotrichia albicollis. Gen. Comp. Biochem. 17:311.Google Scholar
  107. Milligan, L. P. and B.W. McBride. 1985. Shifts in animal requirements across physiological and alimentation states. J. Nutr. 115:1374.PubMedGoogle Scholar
  108. Miselis, R. R. and A. N. Epstein. 1975. Feeding induced by intracerebroventricular 2-deoxy-D-glucose in the rat. Amer. J. Physiol. 229:1438.PubMedGoogle Scholar
  109. Moe, P. W., H. F. Tyrrell and W. P. Flatt. 1971. Energetics of body tissue mobilization. J. Dairy Sci. 54:548.PubMedCrossRefGoogle Scholar
  110. Morley, J. E., T. J. Bartness, B. A. Gosnell and A. S. Levine. 1985. Peptidergic regulation of feeding. Int. Rev. Neurobiol. 27:207.PubMedCrossRefGoogle Scholar
  111. Morley, J. E. and A. S. Levine. 1985. The pharmacology of eating behavior. Annu. Rev. Pharmacol. Toxicol. 25:127.PubMedCrossRefGoogle Scholar
  112. Morley, J. E., A. S. Levine, M. Grace and J. Kneip. 1985. Peptide YY (PYY), a potent orexi-genic agent. Brain Res. 341:200.PubMedCrossRefGoogle Scholar
  113. Morley, J. E. and J. E. Mitchell. 1986. Neurotransmitter/neuromodulator influences on eating. In: E. Ferrari and F. Brambilla (Ed.) Disorders of Eating Behavior: A Psychoneuroendocrine Approach. pp 11–20. Pergamon Press, Elmsford, NY.Google Scholar
  114. Musten, B., D. Peace and G. H. Anderson. 1974. Food intake regulation in the weanling rat: self-selection of protein and energy. J. Nutr. 104:563.PubMedGoogle Scholar
  115. Myers, R. D., H. S. Swortzwelder, J. M. Peinado, T. F. Lee, J. R. Helper, D. M. Denbow and J. M. R. Ferrer. 1986. CCK and other peptides modulate hypothalamic norepinephrine release in the rat: dependence on hunger and satiety. Brain Res. Bull. 17:583.PubMedCrossRefGoogle Scholar
  116. Nicolaidis, S. 1981. Lateral hypothalamic control of metabolic factors related to feeding. Diabe-tologia 20:426.CrossRefGoogle Scholar
  117. Niijima, A. 1977. Nervous regulatory mechanism of blood glucose levels. In: Y. Katsuki, M. Sato, S. F. Takagi and Y. Oomura (Ed.) Food Intake and Chemical Senses, pp 413–426. Japan Sci. Soc. Press, Tokyo.Google Scholar
  118. Novin, D., D. A. VanderWeele and M. Rezek. 1973. Infusion of 2-deoxy-D-glucose into the hepatic portal system causes eating: evidence for peripheral glucoreceptors. Science 181:858.PubMedCrossRefGoogle Scholar
  119. Nzuzi, L. and S. Ritter. 1985. Persistence of glycogen depletion in caudate and hindbrain parallels presistence of feeding after insulin-induced glucoprivation. Soc. Neurosci. Abstr. 11:343.Google Scholar
  120. O’Donohue, T. L., B. M. Chronwall, R. M. Pruss, E. Mezey, J. Z. Kiss, L. E. Eiden, V. J. Nassari, R. E. Tessel, V. M. Pickel, D. A. Dimaggio, A. J. Hotchkiss, W. R. Crowley and Z. Zukowska-Grojec. 1985. Neuropeptide Y and peptide YY neuronal and endocrine systems. Peptides 6:755.PubMedCrossRefGoogle Scholar
  121. Ono, T., Y. Oomura, H. Nishino, K. Sasaki, M. Fukuda and K. Muramoto. 1981. Neural mechanisms of feeding behavior. In: Y Katsuki, R. Norgren and M. Sato (Ed.) Brain Mechanisms of Sensation, pp 271–286. John Wiley and Sons, New York.Google Scholar
  122. Oomura, Y. 1980. Input-output organization in the hypothalamus relating to food intake behavior. In: P. J. Morgane and J. Panksepp (Ed.) Handbook of the Hypothalamus. Vol. II, p 557. Marcel Dekker, New York.Google Scholar
  123. Oomura, Y. and H. Kita. 1981. Insulin acting as a modulator of feeding through the hypothalamus. Diabetologia 20:290.PubMedCrossRefGoogle Scholar
  124. Oomura, Y. and A. Niijima. 1983. Chemosensitive neurons and neural control of pancreatic secretion. In: E. N. Mngola (Ed.) Diabetes 1982, Proceedings of the 11th Congress of the International Diabetes Foundation. pp 201–211. Excerpta Medica, Amsterdam.Google Scholar
  125. Paraneswaran, S. V., A. B. Steffens, G. R. Hervey and L. deRuiter. 1977. Involvement of a humoral factor in regulation of body weight in parabiotic rats. Amer. J. Physiol. 232:R150.Google Scholar
  126. Pardridge, W. M. 1979. The role of blood-brain barrier transport of tryptophan and other neutral amino acids in the regulation of substrate-limited pathways of brain amino acid metabolism. J. Neural Transm. Suppl. 15:43.Google Scholar
  127. Parrott, R. F. and B. A. Baldwin. 1981. Operant feeding and drinking in pigs following intracer-ebroventricular injection of synthetic cholecystokinin octapeptide. Physiol. Behav. 26:419.PubMedCrossRefGoogle Scholar
  128. Parrott, R. F., R. P. Heavens and B. A. Baldwin. 1986. Stimulation of feeding in the satiated pig by intracerebroventricular injection of neuropeptide Y. Physiol. Behav. 36:523.CrossRefGoogle Scholar
  129. Porte, D., Jr. and S. C. Woods. 1981. Regulation of food intake and body weight by insulin. Diabetologia 20:274.PubMedCrossRefGoogle Scholar
  130. Powley, T. L. 1977. The ventromedial hypothalamic syndrome, satiety, and a cephalic phase hypothesis. Psychol. Rev. 84:89.PubMedCrossRefGoogle Scholar
  131. Ritter, R. C, M. Roelke and M. Neville. 1978. Glucoprivic feeding behavior in absence of other signs of glucoprivation. Amer. J. Physiol. 234:E617.PubMedGoogle Scholar
  132. Ritter, R. C, P. G. Slusser and S. Stone. 1981. Glucoreceptors controlling feeding and blood glucose: location in the hindbrain. Science 213:451.PubMedCrossRefGoogle Scholar
  133. Riviere, P. and L. Bueno. 1987. Influence of regimen and insulinemia on orexigenic effects of GRF1–44 in sheep. Physiol. Behav. 39:347.PubMedCrossRefGoogle Scholar
  134. Robinson, D. W. 1974. Food intake regulation in pigs. III. Voluntary food selection between protein-free and protein-rich diets. Brit. J. Nutr. 130:522.Google Scholar
  135. Rogers, Q. R. and P. M. B. Leung. 1973. The influence of amino acids on the neuroregulation of food intake. Fed. Proc. 32:1709.PubMedGoogle Scholar
  136. Rogers, Q. R. and P. M. B. Leung. 1977. The control of food intake: when and how are amino acids involved? In: M. R. Kare and O. Miller (Ed.) The Chemical Senses and Nutrition. pp 213–249. Academic Press, New York.Google Scholar
  137. Rothwell, N. J. and M. J. Stock. 1982. Effects of chronic restriction on energy balance, thermogenic capacity and brown adipose tissue activity in the rat. Biosci. Rep. 2:543.PubMedCrossRefGoogle Scholar
  138. Ruckebusch, Y. and C. H. Malbert. 1986. Stimulation and inhibition of food intake in sheep by centrally-administered hypothalamic releasing factors. Life Sci. 38:929.PubMedCrossRefGoogle Scholar
  139. Russek, M. 1963. An hypothesis on the participation of hepatic glucoreceptors in the control of food intake. Nature 197:79.PubMedCrossRefGoogle Scholar
  140. Shimazu, T. 1981. Central nervous system regulation of liver and adipose tissue metabolism. Diabetologia 20:343.PubMedCrossRefGoogle Scholar
  141. Shimazu, T. 1986. Neuronal control of intermediary metabolism. In: S. Lightman and B. Everitt (Ed.) Neuroendocrinology. p. 304. Blackwell Scientific Publ., Oxford.Google Scholar
  142. Shimazu, T., M. Noma and M. Y. Saito. 1986. Chronic infusion of norepinpherine into the ventromedial hypothalamus induces obesity in rats. Brain Res. 369:215.PubMedCrossRefGoogle Scholar
  143. Skewes, P. A., D. M. Denbow, P. M. Lacy and H. P. Van Krey. 1986. Alteration of food intake following intracerebroventricular administration of plasma from free-feeding domestic fowl. Physiol. Behav. 36:295.PubMedCrossRefGoogle Scholar
  144. Stanley, B. G., D. R. Daniel, A. S. Chin and S. F. Leibowitz. 1985. Paraventricular nucleus injections of peptide YY and neuropeptide Y preferentially enhance carbohydrate ingestion. Peptides 6:1205.PubMedCrossRefGoogle Scholar
  145. Stanley, B. G. and S. F. Leibowitz. 1985. Neuropeptide Y injected in the paraventricular hypothalamus: a powerful stimulant of feeding behavior. Proc., Natl. Acad. Sci. USA 82:3940.CrossRefGoogle Scholar
  146. Steffens, A. B., G. J. Mogenson and J. A. F. Stevenson. 1972. Blood glucose, insulin and free fatty acids after stimulation and lesions of the hypothalamus. Amer. J. Physiol. 222:1446.PubMedGoogle Scholar
  147. Steffens, A. B., A. J. Scheurink and P. G. M. Luiten. 1985. Interference of the nutritional condition of the rat with peripheral glucose regulation determined by CNS mechanisms. Physiol. Behav. 35:405.PubMedCrossRefGoogle Scholar
  148. Stellar, E. 1954. The physiology of motivation. Psychol. Rev. 61:5.PubMedCrossRefGoogle Scholar
  149. Swanson, L. W. 1986. Organization of mammalian neuroendocrine system. In: F. E. Bloom (Ed.) Handbook of Physiology. Sect. 1, Vol. IV, pp 317–363. American Physiological Society, Bethesda.Google Scholar
  150. Tanikawa, K. 1968. Ultrastructural Aspects of the Liver and Its Disorders. pp. 50–55. Igaku Shoin, Tokyo.Google Scholar
  151. Tatemoto, K. 1982. Isolation and characterization of peptide YY (PYY), a candidate gut hormone that inhibits pancreatic exocrine secretion. Proc. Natl. Acad. Sci. USA 79:2514.PubMedCrossRefGoogle Scholar
  152. Trayhurn, P., J. B. Douglas and M. M. McGuckin. 1982. Brown adipose tissue is suppressed during lactation in mice. Nature 298:59.PubMedCrossRefGoogle Scholar
  153. Truett, G. E. 1985. Hypothalamic glucose metabolism in lactating rats. M. S. Thesis. Univ. of Georgia, Athens.Google Scholar
  154. Vaccarino, F. J., F. E. Bloom, J. Rivier, W. Vale and G. F. Koob. 1985. Stimulation of food intake in rats by centrally administered growth hormone-releasing factor. Nature 314:167.PubMedCrossRefGoogle Scholar
  155. Vandermeerschen-Doize, F. and R. Paquay. 1984. Effects of continuous long-term intravenous infusion of long-chain fatty acids on feeding behavior and blood components of adult sheep. Appetite 5:137.PubMedCrossRefGoogle Scholar
  156. Wang, G. H. 1925. The changes in the amont of daily food intake of the albino rat during pregnancy and lactation. Amer. J. Physiol. 71:736.Google Scholar
  157. Wangsness, P. J. and G. H. Soroka. 1979. Effect of energy concentration of milk on voluntary food intake of lean and obese piglets. J. Nutr. 108:595.Google Scholar
  158. Weiss, B. and R. P. Maickel. 1968. Sympathetic nervous control of adipose tissue lipolysis. Int. J. Neuropharmacol. 7:395.PubMedCrossRefGoogle Scholar
  159. Wheeland, R. A., R. J. Martin and A. H. Meier. 1976. The effect of prolactin and CB154 on in vivo lipogenesis in the Japanese quail, and of photostimulation on enzyme patterns in the white throated sparrow. Comp. Biochem. Physiol. 53B:379.Google Scholar
  160. Wilson, P. N. and D. R. Osbourn. 1960. Compensatory growth after undernutrition in animals and birds. Biol. Rev. Cambridge Philos. Soc. 35:324.PubMedGoogle Scholar
  161. Woods, S. C. and D. Porte, Jr. 1974. Neural control of the endocrine pancreas. Physiol. Rev. 54:596.PubMedGoogle Scholar
  162. Woods, S. C, G. J. Taborsky, Jr. and D. Porte, Jr. 1986. Central nervous system control of nutrient homeostasis. In: F. E. Bloom (Ed.) Handbook of Physiology. Sect. 1, Vol. IV, pp 365–411. American Physiological Society, Bethesda.Google Scholar
  163. Wurtman, R. J. and J. P. Fernstrom. 1976. Commentary: control of brain neurotransmitter synthesis by precursor availability and nutritional status. Biochem. Pharmacol. 25:1691.PubMedCrossRefGoogle Scholar
  164. Yoshimatsu, H., A. Niijima, Y. Oomura, K. Yamabe and T. Katufuchi. 1984. Effects of hypothalamic lesion on pancreatic nerve activity in the rat. Brain Res. 303:147.PubMedCrossRefGoogle Scholar
  165. Young, J. B., E. Saville, N. Rothwell, J. Stock and M. J. Landsberg. 1982. Effect of diet and cold on norepinephrine turnover in brown adipose tissue of the rat. J. Clin. Invest. 69:1061.PubMedCrossRefGoogle Scholar
  166. Young, W. S., III and M. J. Kuhar. 1980. Noradrenergic alpha, and alpha2 receptors: light microscopic autoradiographic localization. Proc. Natl. Acad. Sci. USA 77:1696.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Roy J. Martin
    • 1
  • J. Lee Beverly
    • 1
  • Gary E. Truett
    • 1
  1. 1.Department of Foods and NutritionUniversity of GeorgiaAthensUSA

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