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Evolution of Pancreatic Ribonucleases

  • Jaap Beintema
Part of the NATO Advanced Study Institutes Series book series (NSSB, volume 14)

Abstract

Pancreatic ribonucleases form a group of homologous proteins found in considerable quantities in the pancreas of a number of mammalian taxa and of a few reptiles (Barnard, 1969; Beintema et al., 1973). The ribonuclease activity found in different species varies greatly. Large quantities are found in species which are ruminants or have a ruminant-like digestion, but also in a number of species with coecal digestion. Barnard (1969) proposed that elevated levels of pancreatic ribonuclease are the response to the need to digest the large amounts of ribonucleic acid derived from the microflora of the stomach of ruminants. As rumination and ruminant-like digestion have evolved several times independently during the evolution of mammals (Moir, 1968), pancreatic ribonucleases may well show different solutions to the same evolutionary pressure.

Keywords

Ribonucleic Acid Parsimonious Tree Ribonuclease Activity Fallow Deer Pancreatic Ribonuclease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Barnard, E.A., 1969, Biological function of pancreatic ribonuclease. Nature, 221: 340–344.PubMedCrossRefGoogle Scholar
  2. Beintema, J.J., Scheffer, A.J., van Dijk, H., Welling, G.W. and Zwiers, H., 1973, Pancreatic ribonuclease: Distribution and comparisons in mammals. Nat. New Biol., 241: 76–78.Google Scholar
  3. Beintema, J.J., Gaastra, W., Scheffer, A.J. and Welling, G.W., 1976, Carbohydrate in pancreatic ribonucleases. Eur. J. Biochem., 63: 441–448.Google Scholar
  4. Moir, R.J., 1968, Ruminant digestion and evolution. Handbook of physiology—Section 6: Alimentary canal, Vol. V, (Ed.: Code, C.F.): p. 2673–2694. American Physiological Society, Washington, D.C. (U.S.A.).Google Scholar
  5. Van den Berg, A. and Beintema, J.J., 1975, Non-constant evolution rates in pancreatic ribonucleases from rodents: Amino acid sequences of guinea pig, chinchilla and coypu ribonucleases. Nature, 253: 207–210.Google Scholar

Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Jaap Beintema
    • 1
  1. 1.Biochemisch Lab.der Rijksuniversiteit te GroningenGroningenThe Netherlands

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