Neurochemical Factors in Auditory Stimulation and Development of Susceptibility to Audiogenic Seizures
Susceptibility to audiogenic seizures has been observed in several higher animal species, including man. Several inbred strains of mice are known that show either resistance or susceptibility to convulsive seizures during the presentation of an auditory stimulus, and these differences have been attributed to specifically defined genetic backgrounds (1, 2). Mice of the C57BL/6 strain are known to be highly resistant to such seizures (1, 2). In recent studies, Henry (3) and Jumonville (4) reported, independently, that the genetically seizure-resistant C57BL/6 mice can be induced to develop high susceptibility by prior exposure to auditory stimulation during a sensitive period of postnatal development. Similar effects of priming by sound in inducing susceptibility to audiogenic seizures have also been found in other resistant strains of mice (5, 6, 7). It has now been made clear that susceptibility to audiogenic seizures is not only determined by genetic differences but that it is also inducible by prior auditory input, at least in some strains of mice. The findings on this phenomenon of acoustic priming from several behavioral studies and their neurological implications have been reviewed and discussed in the article by K. R. Henry and R. Bowman in this volume.
KeywordsBrain Level Post Partum Auditory Stimulation Postnatal Development Convulsive Seizure
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- 1.Ginsburg, B.E., J.S. Cowen, S.C. Maxson and P.Y. Sze, 1969. Neurochemical effects of gene mutations associated with audiogenic seizures. In: A. Barbeau and J.R. Brunette (eds.), Progress in Neuro-Genetics, Excerpta Medica, Amsterdam, pp. 695–701.Google Scholar
- 2.Ginsburg, B.E., 1967. Genetic parameters in behavioral research. In: J. Hirsch (Ed.), Behavior-Genetic Analysis, McGraw-Hill, New York, pp. 135–153.Google Scholar
- 4.Jumonville, J.E., 1968. Influence of genotype-treatment interactions in studies of “emotionality” in mice. Doctoral dissertation, the University of Chicago.Google Scholar
- 8.Lovell, R.A., 1970. Some neurochemical aspects of convulsion. In: A. Lajtha (Ed.), Handbook of Neurochemistry, Plenum Press, in press.Google Scholar
- 14.Sze, P.Y., 1970. Possible repression of L-glutamic acid decarboxylase by γ-aminobutyric acid in developing mouse brain. Brain Research, in press.Google Scholar
- 16.Haber, B., P.Y. Sze, K. Kuriyama and E. Roberts, 1970. GABA as a repressor of L-glutamic acid decarboxylase in developing check embryo optic lobes. Federation Proceedings 29:348 (abstract).Google Scholar