Neurochemical Factors in Auditory Stimulation and Development of Susceptibility to Audiogenic Seizures

  • Paul Y. Sze


Susceptibility to audiogenic seizures has been observed in several higher animal species, including man. Several inbred strains of mice are known that show either resistance or susceptibility to convulsive seizures during the presentation of an auditory stimulus, and these differences have been attributed to specifically defined genetic backgrounds (1, 2). Mice of the C57BL/6 strain are known to be highly resistant to such seizures (1, 2). In recent studies, Henry (3) and Jumonville (4) reported, independently, that the genetically seizure-resistant C57BL/6 mice can be induced to develop high susceptibility by prior exposure to auditory stimulation during a sensitive period of postnatal development. Similar effects of priming by sound in inducing susceptibility to audiogenic seizures have also been found in other resistant strains of mice (5, 6, 7). It has now been made clear that susceptibility to audiogenic seizures is not only determined by genetic differences but that it is also inducible by prior auditory input, at least in some strains of mice. The findings on this phenomenon of acoustic priming from several behavioral studies and their neurological implications have been reviewed and discussed in the article by K. R. Henry and R. Bowman in this volume.


Brain Level Post Partum Auditory Stimulation Postnatal Development Convulsive Seizure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Ginsburg, B.E., J.S. Cowen, S.C. Maxson and P.Y. Sze, 1969. Neurochemical effects of gene mutations associated with audiogenic seizures. In: A. Barbeau and J.R. Brunette (eds.), Progress in Neuro-Genetics, Excerpta Medica, Amsterdam, pp. 695–701.Google Scholar
  2. 2.
    Ginsburg, B.E., 1967. Genetic parameters in behavioral research. In: J. Hirsch (Ed.), Behavior-Genetic Analysis, McGraw-Hill, New York, pp. 135–153.Google Scholar
  3. 3.
    Henry, K.R., 1967. Audiogenic seizure susceptibility induced in C57BL/6J mice by prior auditory exposure. Science 158: 938–940.PubMedCrossRefGoogle Scholar
  4. 4.
    Jumonville, J.E., 1968. Influence of genotype-treatment interactions in studies of “emotionality” in mice. Doctoral dissertation, the University of Chicago.Google Scholar
  5. 5.
    Fuller, J.L., and R.L. Collins, 1968. Mice unilaterally sensitized for audiogenic seizures. Science 162:1295.PubMedCrossRefGoogle Scholar
  6. 6.
    Fuller, J.L., and R.L. Collins, 1968. Temporal parameters of sensitization for audiogenic seizures in SLJ/J mice. Developmental Psychobiology 1:185–188.CrossRefGoogle Scholar
  7. 7.
    Fuller, J.L., and F.H. Sjursen Jr., 1967. Audiogenic seizures in eleven mouse strains. Journal of Heredity 58:135–140.PubMedGoogle Scholar
  8. 8.
    Lovell, R.A., 1970. Some neurochemical aspects of convulsion. In: A. Lajtha (Ed.), Handbook of Neurochemistry, Plenum Press, in press.Google Scholar
  9. 9.
    Roberts, E., and K. Kuriyama, 1968. Biochemical-physiological correlations in studies of the γ-aminobutyric acid system. Brain Research 8:1–35.PubMedCrossRefGoogle Scholar
  10. 10.
    Graham, L.T., and M.H. Aprison, 1966. Fluorometric determination of aspartate, glutamate, and γ-aminobutyrate in nerve tissue using enzymic methods. Analytical Biochemistry 15:487–497.PubMedCrossRefGoogle Scholar
  11. 11.
    Mead, J.A.R., and K.T. Finger, 1961. Single extraction method for the determination of norepinephrine. Biochemical Pharmacology 6:52–58.PubMedCrossRefGoogle Scholar
  12. 12.
    Wise, C.D., 1967. The fluorometric determination of brain serotonin. Analytical Biochemistry 20:369–374.PubMedCrossRefGoogle Scholar
  13. 13.
    Baxter, C.F., and E. Roberts, 1961. Elevation of γ-aminobutyric acid in brain: selective inhibition of γ-aminobutyric-α-ketoglutaric acid transaminase. Journal of Biological Chemistry 236: 3287–3294.PubMedGoogle Scholar
  14. 14.
    Sze, P.Y., 1970. Possible repression of L-glutamic acid decarboxylase by γ-aminobutyric acid in developing mouse brain. Brain Research, in press.Google Scholar
  15. 15.
    Tewari, S., and C.F. Baxter, 1969. Stimulatory effect of γ-aminobutyric acid upon amino acid incorporation into protein by a ribosomal system from immature rat brain. Journal of Neurochemistry 16:171–180.PubMedCrossRefGoogle Scholar
  16. 16.
    Haber, B., P.Y. Sze, K. Kuriyama and E. Roberts, 1970. GABA as a repressor of L-glutamic acid decarboxylase in developing check embryo optic lobes. Federation Proceedings 29:348 (abstract).Google Scholar

Copyright information

© Plenum Press, New York 1970

Authors and Affiliations

  • Paul Y. Sze
    • 1
  1. 1.Department of Biobehavioral SciencesThe University of ConnecticutStorrsUSA

Personalised recommendations