Influence of Age, Auditory Conditioning, and Environmental Noise on Sound-Induced Seizures and Seizure Threshold in Mice

  • Gregory B. Fink
  • W. B. Iturrian


Experimental seizures may be evoked in animals by electrical, chemical, or sensory technics. Sound is the most frequently employed sensory stimulus. With sufficient stimulus intensity, all the technics produce a maximal seizure characterized by a sequence of tonic flexion and tonic extension; the pattern of submaximal seizure activity varies with the type of evoking stimulus and its intensity (1,2). Because of their simplicity and reliability, electroshock and chemoshock tests have been widely employed to study the convulsive process and to evaluate drug activity. Several tests, e.g., maximal electroshock seizure and low frequency electroshock seizure tests, are well standardized and have a reasonable neurophysiological explanation (1,2).


Seizure Threshold Audiogenic Seizure Seizure Susceptibility Maximal Electroshock Seizure Test Sound 
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Copyright information

© Plenum Press, New York 1970

Authors and Affiliations

  • Gregory B. Fink
    • 1
  • W. B. Iturrian
    • 2
  1. 1.Department of PharmacologyOregon State UniversityCorvallisUSA
  2. 2.Department of PharmacologyUniversity of GeorgiaAthensUSA

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