Acoustic Priming of Audiogenic Seizures in Mice
The audiogenic seizure is a classic example of an extra-auditory physiological effect of audible sound. This distinctive behavior has been studied in animals in the hope that knowledge of its mechanism might aid in the understanding of both sensory-induced and spontaneous seizures in man. Recently, it has been discovered that prior intense auditory stimulation can induce or enhance susceptibility to audiogenic seizures in mice. This “acoustic priming” effect represents a new phenomenon which may be useful in seizure research, especially if a similar effect is observed in man. This chapter describes a series of on-going experiments which have been designed to examine the priming effect.
KeywordsInbred Mouse Temporal Summation Retrograde Amnesia Sensitive Period Electroconvulsive Shock
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