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Reflux Nephropathy

  • John Hodson

Abstract

“Reflux Nephropathy” is a term coined to encompass the spectrum of kidney disease forms in which vesico-ureteral reflux plays a major etiologic role; a group that has morbic anatomical changes with varying but distinctive features. Urinary infection and raised pressure within the urinary tract are commonly associated, but the ways in which those three etiologic factors combine to produce the differing disease entities is not yet established. The renal damage tends to commence at a very early age; and its more severe complications, severe hypertension and renal failure, are well documented from as young as five years onwards, the bulk of the clinical impact being between the ages of 10 and 30 years. Because the essence of the disease is severe focal fibrosis which strangles the parenchyma it enmeshes and which is largely unaffected by treatment once it has become established, the only hopeful method of approach, as in the case of cystic fibrosis, lies in early diagnosis and prevention rather than later amelioration or cure.

Keywords

Polar Region Renal Damage Vesicoureteric Reflux Renal Scarring Posterior Urethral Valve 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • John Hodson
    • 1
  1. 1.Diagnostic Radiol.Yale Univ. School of Medicine and Yale New Haven HospitalNew HavenUSA

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