Principles of Diuretic Therapy in Edematous Conditions

  • George A. Richard
  • Eduardo H. Garin
  • Abdollah Iravani
  • Robert S. FennellIII
  • John K. Orak


The clinical use of diuretics should be based on a good understanding of the pathophysiology of edema and the disease being treated, the pharmacology of the diuretics and their reported side effects. This knowledge allows one the best opportunity to effectively and safely match the mechanism of action of the diuretic to the altered physiology caused by the disease. The major clinical conditions for which diuretics have been used in the treatment of edema are shown in Table 1. It is generally agreed that, whatever the pathophysiology of the primary disease, the retention of sodium by the kidney ultimately determines the magnitude of the fluid overload and consequent edema formation. Thus, an understanding of normal salt and water handling by the kidney is essential.


Glomerular Filtration Rate Nephrotic Syndrome Renal Blood Flow Diuretic Therapy Tubular Reabsorption 
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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • George A. Richard
    • 1
  • Eduardo H. Garin
    • 1
  • Abdollah Iravani
    • 1
  • Robert S. FennellIII
    • 1
  • John K. Orak
    • 1
  1. 1.Div. Pediatr. Nephrol., Dept. Pediatr.Col. Med. Univ. Fla.GainesvilleUSA

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