Usage of Antibiotics in Children with Renal Insufficiency
The control of infection remains an important aspect of treatment in patients with renal insufficiency. A large fraction of deaths associated with acute renal failure as well as the three phases of end stage renal disease, the period of chronic uremia, dialysis and transplantation, are due to infection. A large fraction of patients with renal disease need antibiotics for treating bacterial infections exclusive of urinary tract infection. Little data is available in children with renal failure on the incidence of infection or its treatment with anti-infectious agents. In a recent survey of our transplantation experience involving 107 transplants at St. Christopher’s Hospital for Children, positive blood cultures were obtained in 10 patients in the initial 21 days following the transplant (1). Moreover, antibiotics have been administered for a variety of infectious problems to virtually all of our patients with end stage renal disease. In one report of 497 children undergoing maintenance dialysis, infection was responsible for death in 13 percent (2). Thus, the need to understand how best to administer antibiotics to uremic children is obvious.
KeywordsPeritoneal Dialysis Renal Insufficiency Peritoneal Membrane Maintenance Dialysis Drug Removal
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