Highlights Pathology and Interstitial Nephritis
Interstitial nephritis of the primary type is characterized by the appearance of inflammatory cells in the interstitium accompanied by variable degrees of tubular damage but with no primary glomerular change. The interstitium is edematous in the early or acute stages but fibrosis is the rule in the chronic type. The cells are usually of a chronic type — lymphocytes, monocytes, plasma cells and eosinophiles — and these appear at an early stage in the process. In certain forms of glomerulonephritis there is an intense interstitial reaction and this can be referred to as secondary interstitial nephritis.