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Aluminum in Chronic Renal Failure: A Pediatric Perspective

  • Martin S. Polinksy
  • Alan B. Gruskin
  • H. Jorge Baluarte
  • James W. Prebis
  • Abdelaziz Y. Elzouki

Abstract

During the past decade it has been suggested that aluminum may be substantially more toxic to the human body than had previously been thought (1). Much evidence has accumulated implicating aluminum, either directly or indirectly, in the pathogenesis of several forms of progressive central nervous system dysfunction, bone disease, and possibly cardiac and hematologic disturbances. For reasons which will be discussed below patients with renal insufficiency may be at greater risk of developing these sequelae which appear to be associated with an increasingly positive body aluminum balance. Although these problems have been reported almost exclusively in adults, it has become increasingly apparent that pediatric patients may be similarly affected. Consequently, an understanding of the current status of aluminum as a potential toxin is important to those caring for children with chronic renal disease.

Keywords

Chronic Renal Insufficiency Renal Osteodystrophy Aluminum Level Osteitis Fibrosa Neurofibrillary Degeneration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • Martin S. Polinksy
    • 1
  • Alan B. Gruskin
    • 1
  • H. Jorge Baluarte
    • 1
  • James W. Prebis
    • 1
  • Abdelaziz Y. Elzouki
    • 1
  1. 1.Dept. Pediatr.St. Christopher’s Hosp. for Children and Temple Univ. Sch. Med.PhiladelphiaUSA

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