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Hyperlipidemia Secondary to Renal Disease

  • Guido O. Perez
  • Sung Lan Hsia

Abstract

Hyperlipidemia is a common metabolic complication in patients with chronic renal failure. In view of the association of hyperlipidemia with atherosclerosis, and the greatly increased incidence of atherosclerosis among uremic patients, the study of lipid metabolism in chronic renal failure has drawn much attention. A brief review of current literature and the results of some of our recent studies are presented in this paper.

Keywords

Nephrotic Syndrome Chronic Renal Failure Dialysis Patient Cholesteryl Ester Lipoprotein Lipase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Lowrie, E.G., Lazarus, J.M., Mocelin, A.J. et al.: Survival of patients undergoing chronic hemodialysis and renal transplantation. N. Engl. J. Med. 288: 864, 1973.CrossRefGoogle Scholar
  2. 2.
    Linder, A., Charra, B., Sherrard, D.J. et al.: Accelerated atherosclerosis in prolonged maintenance hemodialysis. N. Engl. J. Med. 290: 697, 1974.CrossRefGoogle Scholar
  3. 3.
    Burke, J.F., Francos, G.C., Moore, L.L. et al.: Accelerated atherosclerosis in chronic dialysis patients — Another look. Nephron 21: 181, 1978.PubMedCrossRefGoogle Scholar
  4. 4.
    Bagdade, J.D., Porte, D., Jr. and Bierman, E.L.: Hypertriglyceridemia: A metabolic consequence of chronic renal failure. N. Engl. J. Med. 279: 181, 1968.PubMedCrossRefGoogle Scholar
  5. 5.
    Ibels, L.S., Simons, L.A., King, J.O. et al.: Studies on the nature and causes of hyperlipidemia in uremia, maintenance hemodialysis and renal transplantation. Q.J. Med. 44: 601, 1976.Google Scholar
  6. 6.
    Bagdade, J.D., Casaretto, A. and Albers, J.: Effects of chronic uremia, hemodialysis and renal transplantation on plasma lipids and lipoproteins in man. J. Lab. Clin. Med. 87: 37, 1976.Google Scholar
  7. 7.
    Ibels, S.L., Reardon, M.F. and Nestel, P.J.: Plasma postheparin lipolytic activity and triglyceride clearance in uremic and hemodialysis patients and renal allograft recipients. J. Lab. Clin. Med. 87: 648, 1976.PubMedGoogle Scholar
  8. 8.
    Dombeck, D.H., Lindholm, D.D. and Vieira, J.A.: Lipid metabolism in uremia and the effects of dialysate glucose and oral androgen therapy. Transactions ASAIO 13: 150, 1973.CrossRefGoogle Scholar
  9. 9.
    Kaye, J.P., Moorhead, J.F. and Willis, M.R.: Plasma lipids in patients with chronic renal failure. Clin. Chim. Acta. 44: 301, 1973.PubMedCrossRefGoogle Scholar
  10. 10.
    Henck, C.C., Ritz, E., Liersch, M. et al.: Serum lipids in renal insufficiency. Am. J. Clin. Nutr. 31: 1547, 1978.Google Scholar
  11. 11.
    Bagdade, J., Yee, E. and Pykalisto, O.J.: Parathyroid hormone and triglyceride transport: Effects on triglyceride secretion rates and adipose tissue lipoprotein lipase in the rat. Horm. Metab. Res. 10: 443, 1978.PubMedCrossRefGoogle Scholar
  12. 12.
    Mordasini, R., Frey, F., Flury, W. et al.: Selective deficiency of hepatic triglyceride lipase in uremic patients. N. Engl. J. Med. 297: 1362, 1977.PubMedCrossRefGoogle Scholar
  13. 13.
    Cattran, D.C., Steiner, G., Fenton, S.S.A. et al.: Hypertriglyceridemia in uremia and the use of triglyceride turnover to define pathogenesis. Transactions ASAIO 20: 148, 1974.Google Scholar
  14. 14.
    Boyer, J.L. and Scheig, R.L.: Inhibition of post-heparin lipolytic activity in uremia and its relationship to hypertriglyceridemia. Proc. Soc. Exp. Biol. Med. 134: 603, 1970.PubMedGoogle Scholar
  15. 15.
    Murase, T., Cattran, D.C., Rubenstein, B. et al.: Inhibition of lipoprotein lipase by uremic plasma: A possible cause of hypertriglyceridemia. Metabolism 24: 1279, 1975.PubMedCrossRefGoogle Scholar
  16. 16.
    Austin, W. and Nestel, P.J.: The effect of glucose and insulin in vitro on the uptake of triglyceride and on lipoprotein lipase activity in fat pads from normal fed rats. Biochem. Biophys. Acta 164: 59, 1968.PubMedGoogle Scholar
  17. 17.
    Rapoport, J., Aviram, M., Chaimovitz, C. et al.: Defective high-density lipoprotein composition in patients on chronic hemodialysis. N. Engl. J. Med. 299: 1326, 1978.PubMedCrossRefGoogle Scholar
  18. 18.
    Cattran, D.C., Fenton, S.A., Wilson, D.R. et al.: Defective triglyceride removal in lipemia associated with peritoneal dialysis and hemodialysis. Ann. Intern. Med. 85: 29, 1976.PubMedGoogle Scholar
  19. 19.
    Bagdade, J.D., Yee, E., Wilson, D.E. et al.: Hyperlipidemia in renal failure: Studies of plasma lipoproteins, hepatic triglyceride production, and tissue lipoprotein lipase in a chronically uremic rat model. J. Lab. Clin. Med. 91: 176, 1978.PubMedGoogle Scholar
  20. 20.
    Quellhorst, E., Rieger, J., Doht, B. et al.: Treatment of chronic uraemia by an ultrafiltration artificial kidney -first clinical experience. Proc. Europ. Dial. Transpl. Assoc. 12: 314, 1976.Google Scholar
  21. 21.
    Choi, E.S.K., Chung, T., Morrison, R. et al.: Hypertriglyceridemia in hemodialysis patients during oral dromostanolone therapy for anemia. Am. J. Clin. Nutr. 27: 901, 1974.PubMedGoogle Scholar
  22. 22.
    Brunzell, J.D., Albers, J.J., Haas, L.B. et al.: Prevalence of serum lipid abnormalities in chronic hemodialysis. Metab. 26: 903, 1977.CrossRefGoogle Scholar
  23. 23.
    Daubrese, J.C., Lerson, G., Plomteux, G. et al.: Lipids and lipoproteins in chronic uraemia. A study of the influence of regular hemodialysis. Europ. J. Clin. Invest. 6: 159, 1976.CrossRefGoogle Scholar
  24. 24.
    Berger, M., James, G.P., Davis, E.R. et al.: Hyperlipidemia in uremic children: Response to peritoneal dialysis and hemodialysis. Clin. Nephrol. 9: 19, 1978.PubMedGoogle Scholar
  25. 25.
    Davidson, W.D., Morin, R.J., Rorke, S.J. et al.: The role of acetate in dialysate for hemodialysis. Proc. 10th Ann. Contr. Conf. Artif. Kidney Prog. NIAMDD, DREW Publication No. (NIH) 77–1442, 1977, p. 15.Google Scholar
  26. 26.
    Miller, G.J. and Miller, N.E.: Plasma-high-density lipoprotein concentration and development of ischaemic heart disease. Lancet 1: 16, 1975.PubMedCrossRefGoogle Scholar
  27. 27.
    Stein, Y., Galngeaud, M.C., Fainru, M. et al.: The removal of cholesterol from aortic smooth muscle cells in culture and Landschutz ascites cells by fractions of human high-density lipoprotein. Biochim. Biophys. Acta 380: 106, 1975.PubMedGoogle Scholar
  28. 28.
    Baily, J.M.: Regulation of cell cholesterol content. In Porter, R. and Knight, J. (eds.): Atherosclerosis: Initiating Factors. Amsterdam: Elsevier, 1973, p. 63.Google Scholar
  29. 29.
    Bohdjers, G. and Buorkerud, S.: Cholesterol transfer between arterial smooth muscle tissue and serum lipoprotein in vitro. Artery 1: 3, 1974.Google Scholar
  30. 30.
    Glomset, J.A.: The plasma lecithin cholesterol acyl transferase reaction. J. Lipid Res. 9: 155, 1968.PubMedGoogle Scholar
  31. 31.
    Koschinsky, T., Carew, T.E. and Steinberg, D.: Binding, internalization, and degradation of high density lipoprotein by cultured normal human fibroblasts. J. Lipid Res. 18: 438, 1977.Google Scholar
  32. 32.
    Guarnieri, G. F., Moracchiello, M., Campanacci, L. et al.: Lecithin-cholesterol acyl transferase (LCAT) activity in chronic uremia. Kidney Int. 13: S-26, 1978.Google Scholar
  33. 33.
    Brunzell, J.D., Albers, J.J., Haas, L.B. et al.: Prevalence of serum lipid abnormalities in chronic dialysis. Metab. 26: 903, 1977.CrossRefGoogle Scholar
  34. 34.
    Bagdade, J.D. and Albers, J.J.: Plasma high-density lipoprotein concentrations in chronic hemodialysis and renal transplant patients. N. Engl. J. Med. 296: 1436, 1977.PubMedCrossRefGoogle Scholar
  35. 35..
    Perez, G.O., Hsia, S.L., Christakis, G. et al.: Serum cholesterol binding reserve and high density lipoprotein cholesterol in patients on maintenance hemodialysis. Horm. Metab. Res. (In press).Google Scholar
  36. 36.
    Hsia, S.L., Chao, Y.S., Hennekens, C.H. et al.: Decreased serum cholesterol binding reserve in premature myocardial infarction. Lancet 2: 1000, 1975.PubMedCrossRefGoogle Scholar
  37. 37.
    Hsia, S.L., Fishman, L.M., Briese, F.W. et al.: Decreased serum cholesterol binding reserve in diabetes mellitus. Diabetes Care 1: 89, 1978.PubMedCrossRefGoogle Scholar
  38. 38.
    Perez, G.O., Levine, S., Gomez, E. et al.: Serum cholesterol binding reserve in patients with the nephrotic syndrome. Nephron 24: 146, 1979.PubMedCrossRefGoogle Scholar
  39. 39.
    Chajek, T. and Fielding, C.J.: Isolation and characterization of a human serum choiesteryl ester transfer protein. Proc. Natl. Acad. Sci. U.S.A. 75: 3445, 1978.PubMedCrossRefGoogle Scholar
  40. 40.
    Nestel, P.J., Reardon, M. and Billington, T.: In vivo transfer of cholesteryl esters from high-density lipoproteins to very low-density lipoproteins in man. Biochim. Biophys. Acta 573: 403, 1979.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • Guido O. Perez
    • 1
  • Sung Lan Hsia
    • 1
  1. 1.Depts. Med., Dermatol., Biochem.Univ. Miami Sch. Med. and Vet. Adm. Med. CenterMiamiUSA

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