Highlights Acute Non-Bacterial Tubulointerstitial Nephritis (TIN)
Clinical material was constituted of 29 children, 51% below one year of age. There were 18 males and 11 females. Twenty-three out of the 29 patients had the antecedent of drug ingestion just prior to the onset of the renal manifestations: gentamycin, kana-mycin, ampicillin, streptomycin, sulphonamides, cefalosporin, siso-mycin, diphenylhydantoin, diphenylhydramine were the incriminated drugs. Four patients had salmonellosis, scarlet fever, and upper respiratory infections, respectively, at the time TIN started. There were no antecedents in two children. Most of the patients presented with hematuria and some with acute renal failure. Urinary findings were hematuria, proteinuria and glycosuria. High values of BUN and serum creatinine were found in 10 patients. Percutaneous renal biopsy was done in 9 patients: interstitial edema, fibrosis and mononuclear cell infiltration were the predominant findings. No immunofluorescence was present in the tubulointersti-tial lesions.