Highlights Immunologically Mediated Tubulointerstitial Nephritis in Children
Several immunologically mediated mechanisms may lead to injury of renal tubules and interstitial tissue resulting in tubulointer-stitial nephritis (TIN). The distinguishing features of these mechanisms are based upon their immunofluorescent microscopic (IF) pattern. Tubular linear deposits of immunoglobulins (Ig) suggest the presence of circulating antitubular basement membrane (TBM) antibodies. Granular deposits of Ig and/or complement (C) are likely related to the presence of immune complexes (IC). In the absence of deposits, a cell-mediated reaction may be suggested. These mechanisms have been well studied in experimental models. They may also be observed in man. We report about 14 children with proven or presumed immunologically mediated TIN.