Biochemical and Biological Characterization of LH and FSH Expressed by Recombinant DNA Technology

  • Scott Chappel
Part of the Biochemical Endocrinology book series (BIOEND)


The interactions between the central nervous system, anterior pituitary gland and gonads are complex and in a state of dynamic equilibrium. Endocrine communication between these three organs is affected by the surrounding internal and external milieu (1,2). With regard to the pituitary gland, it has been well-documented that alterations in the rates of gonadotropin secretion are accompanied by changes in hormone biosynthesis and therefore pituitary concentration (3). In addition to an effect upon the rate of hormone synthesis and secretion, the endocrine milieu influences the co- and post-translational characteristics of gonadotropins (1). Information about the internal and external environment is obtained by the CNS and/or pituitary gland and causes dramatic changes in the rate of LH and FSH synthesis and secretion as well as the biochemical characteristics of the gonadotropic signals. This mechanism allows the organism to adjust its gonadal function according to the dictates of the surrounding environment. Thus, pituitary tissue obtained at different points in time may vary in gonadotropin content or quality.


Culture Granulosa Cell Terminal Sialic Acid Residue Pituitary Preparation Superovulatory Response Bovine Alpha 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Scott Chappel
    • 1
  1. 1.Integrated Genetics Inc.FraminghamUSA

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