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Cellular and Sub-Cellular Localization of Brain Neurotensin Receptors

  • Alain Beaudet
  • Eva Szigethy
  • Jean Pierre Kessler
  • Corinne Dana
  • Jean Mazella
  • Emmanuel Moyse
Part of the Biochemical Endocrinology book series (BIOEND)

Abstract

Neurotensin (NT) is a tridecapeptide which was first isolated (Carraway and Leeman, 1973) and sequenced (Carraway and Leeman, 1975) from bovine hypothalamus and later shown by radioimmunoassay (Carraway and Leeman, 1976; Uhl and Snyder, 1976; Kobayashi et al., 1977) and immunohistochemistry (Jennes et al., 1982; Uhl et al., 1977; Uhl et al., 1979) to be distributed throughout the central nervous system (CNS) of various mammalian species, including man. Biochemical and electrophysiological evidence support the view that NT acts as a neurotransmitter/neuromodulator in the mammalian CNS. It is concentrated in synaptosomal fractions (Uhl and Snyder, 1976), is released in a Ca++-dependent manner by depolarizing stimuli (Iversen et al., 1978; Maeda and Frohman, 1981), and is rapidly inactivated by synaptosomal enzymatic systems (Checler et al., 1983, 1984, 1985). It was shown to exert powerful depolarizing effects on neurons in several brain regions (Young et al., 1978; Henry, 1982; Pinnock, 1985) and to activate intracellular second messenger systems both in cell cultures (Amar et al., 1985) and in brain slices (Gilbert et al., 1984; Goedert et al., 1984).

Keywords

Substantia Nigra Ventral Tegmental Area Basal Forebrain Nucleus Basalis Nodose Ganglion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Alain Beaudet
    • 1
  • Eva Szigethy
    • 1
  • Jean Pierre Kessler
    • 1
  • Corinne Dana
    • 2
  • Jean Mazella
    • 3
  • Emmanuel Moyse
    • 1
  1. 1.Montreal Neurological InstituteMontrealCanada
  2. 2.INSERM U.55Centre de Recherches Saint-AntoineParis, Cedex 12France
  3. 3.Centre de Biochimie du CNRSUniversité de NiceNice, CedexFrance

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