Cellular Mechanisms of Peptide Processing: Focus on α-Amidation
It is now well accepted that a vast array of peptides play essential roles in intercellular communication in both the nervous and endocrine systems. Many neurons contain both a classical neurotransmitter and a peptide (Krieger, 1983; Jones & Hendry, 1986). While we know a great deal about the control mechanisms affecting neuronal synthesis, storage and secretion of classical neurotransmitters such as the catecholamines and acetylcholine, we know relatively little about the precise way in which neuronal peptides are regulated. Our lack of knowledge concerning the mechanisms by which the synthesis, storage and secretion of bioactive peptides can be manipulated stems in large part from the relative lack of knowledge about the specific enzymes involved in converting inactive peptide precursors into their final bioactive products.
KeywordsTyrosine Hydroxylase Secretory Granule Amidated Peptide Classical Neurotransmitter Aromatic Amino Acid Decarboxylase
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