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Cellular Mechanisms of Peptide Processing: Focus on α-Amidation

  • Richard E. Mains
  • Victor May
  • Edward I. Cullen
  • Betty A. Eipper
Part of the Biochemical Endocrinology book series (BIOEND)

Abstract

It is now well accepted that a vast array of peptides play essential roles in intercellular communication in both the nervous and endocrine systems. Many neurons contain both a classical neurotransmitter and a peptide (Krieger, 1983; Jones & Hendry, 1986). While we know a great deal about the control mechanisms affecting neuronal synthesis, storage and secretion of classical neurotransmitters such as the catecholamines and acetylcholine, we know relatively little about the precise way in which neuronal peptides are regulated. Our lack of knowledge concerning the mechanisms by which the synthesis, storage and secretion of bioactive peptides can be manipulated stems in large part from the relative lack of knowledge about the specific enzymes involved in converting inactive peptide precursors into their final bioactive products.

Keywords

Tyrosine Hydroxylase Secretory Granule Amidated Peptide Classical Neurotransmitter Aromatic Amino Acid Decarboxylase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Richard E. Mains
    • 1
  • Victor May
    • 1
  • Edward I. Cullen
    • 1
  • Betty A. Eipper
    • 1
  1. 1.Department of NeuroscienceThe Johns Hopkins University School of MedicineBaltimoreUSA

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