Molecular Cloning and Characterization of Plant 3-Hydroxy-3-Methylglutaryl Coenzyme a Reductase

  • M. Monfar
  • C. Caelles
  • L. Balcells
  • A. Ferrer
  • F. G. Hegardt
  • A. Boronat
Part of the Recent Advances in Phytochemistry book series (RAPT, volume 24)


Mevalonic acid is the specific precursor of the vast array of isoprenoid compounds present in plants. These compounds play essential roles in plant growth and development and include growth regulators (gibberellins and abscisic acid), side chains of many biologically active molecules (chlorophylls, prenylquinones and ubiquinone), carotenoids, dolichols and sterols. In addition, individual groups of plants have evolved specific isoprenoid compounds for specific functions, such as attractants for insect pollination, or as phytoalexins for defense against fungal or bacterial infection. Mevalonate is synthesized from 3-hydroxy-3-methyl-glutaryl coenzyme A (HMG-CoA) in a reaction catalyzed by the enzyme HMG-CoA reductase (EC This enzymatic activity has been described in a large number of plants (for recent reviews1–2); in all cases the enzyme is membrane bound. The main subcellular location of the enzyme activity appears to be the endoplasmic reticulum, but it has also been reported to be associated with mitochondrial and plastid membranes.3–4


Amino Acid Sequence Alignment Mevalonic Acid Plant Enzyme Isoprenoid Biosynthesis Radish Seedling 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • M. Monfar
    • 1
  • C. Caelles
    • 1
  • L. Balcells
    • 1
  • A. Ferrer
    • 1
  • F. G. Hegardt
    • 1
  • A. Boronat
    • 1
  1. 1.Unitat de Bioquímica, Facultat de FarmaciaUniversitat de BarcelonaBarcelonaSpain

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