Molecular Isolation and Preliminary Characterisation of a Duplicated Esterase Locus in Drosophila buzzatii

  • Peter East
  • Anne Graham
  • Gillian Whitington
Part of the Monographs in Evolutionary Biology book series (MEBI)


Most plants and animals possess a great variety of esterase isozymes of broad substrate specificity and diverse patterns of developmental expression. In the house mouse Mus musculus several loci encoding esterases have been mapped in two clusters on chromosome 8 (Peters, 1982). Some of these loci are very tightly linked and their protein products have similar subunit molecular weights. Similar clusters of apparently homologous loci are found in related species (Peters, 1982), notably the laboratory rat, Rattus norvegicus (Hedrich and von Deimling, 1987), where two clusters are found 17 map units apart on linkage group V. The occurrence of very tightly linked clusters suggests an origin by repeated tandem duplication for some of these esterases. Interestingly, individual members of a cluster are characterised by essentially unique patterns of developmental expression (Peters, 1982; Hedrich and von Deimling, 1987). This implies a relatively rapid alteration of the elements controlling the spatial and temporal expression of these proteins.


Esterase Gene Esterase Isozyme Putative Intron Peach Potato Aphid Esterase Locus 
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Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • Peter East
    • 1
  • Anne Graham
    • 1
  • Gillian Whitington
    • 1
  1. 1.Department of Animal ScienceUniversity of New EnglandArmidaleAustralia

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