Interactions of Lanthanides with Other Molecules of Biochemical Interest
Two main motives have encouraged studies of the interactions of the lanthanides with mononucleosides and mononucleotides. The first follows from the realization that the metabolically active forms of many nucleotides are ones in which a metal ion is coordinated. Best studied is the ATP-Mg complex which forms the physiologically active substrate for ATP-requiring reactions. As Mg2+, like Ca2+, is spectroscopically un-informative, it, too, has been replaced by Ln3+ ions for experimental studies. The second motive has been to use paramagnetic lanthanides in NMR spectroscopic investigations aimed at determining the solution structures of these molecules.
KeywordsCircular Dichroism Circular Dichroism Spectrum Phosphate Moiety Shift Reagent Anticodon Loop
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