Diadenosine Tetraphosphate and Diadenosine Tetraphosphate-Binding Proteins in Developing Embryos of Artemia

  • Alexander G. McLennan
  • Mark Prescott
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 179)


Diadenosine 5′,5‴-P1, P4-tetraphosphate (Ap4A) has been detected in a number of eukaryotic cells and tissues and its intracellular concentration found to vary between 0.05 to 0.1 pmol/106 cells in resting cells to 5–10 pmol/106 cells in rapidly dividing populations (1). It has recently been found to bind tightly to one subunit of a high molecular weight DNA polymerase-α complex from calf thymus (2) and HeLa cells (3). These facts have contributed to the idea that Ap4A may be an important regulatory nucleotide required for the initiation of DNA replication (4).


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Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • Alexander G. McLennan
    • 1
  • Mark Prescott
    • 1
  1. 1.Department of BiochemistryUniversity of LiverpoolLiverpoolUK

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