DNA-Binding Proteins in Replicating and Mitotically Arrested Brain Neurons

  • Clive C. Kuenzle
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 179)


Neurons of the cerebral cortex and the cerebellum of the rat appear to be excellently suited to study the signals mediating mitotic arrest in vivo. This is because the time course of neuronal differentiation is known exactly in both these parts of the brain and in this species. A decisive event in neuronal differentiation is the transition from proliferating precursor cells to non-dividing, terminally differentiating neurons. This takes place just about term in the cortex but only after birth in the cerebellum.


Mitotic Arrest Cerebellar Neuron Proliferate Precursor Cell Reductive Methylation Cerebral Cortex Neuron 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Heizmann, C.W., Arnold, E.M. and Kuenzle, C.C. (1980) J. Biol. Chem. 255, 11504.PubMedGoogle Scholar
  2. 2.
    Heizmann, C.W., Arnold, E.M. and Kuenzle, C.C. (1982) Eur. J. Biochem. 127, 57.PubMedCrossRefGoogle Scholar
  3. 3.
    Winkler, G.C. (1981) Thesis, School of Veterinary Medicine, University of Zürich.Google Scholar
  4. 4.
    Cox, M.M. and Lehman, I.R. (1981) Nucleic Acids Res. 9, 389.PubMedCrossRefGoogle Scholar
  5. 5.
    Reinhard, P., Maillart, P., Schluchter, M., Gautschi, J.R. and Schindler, R. (1979) Biochim. Biophys. Acta 564, 141.PubMedCrossRefGoogle Scholar
  6. 6.
    Biocca, S., Cattaneo, A. and Calissano, P. (1983) Embo J. 2, 643.PubMedGoogle Scholar
  7. 7.
    Zimmerman, S.B. (1982) Annu. Rev. Biochem. 51, 395.PubMedCrossRefGoogle Scholar
  8. 8.
    Neidle, S. (1983) Nature 302, 574.PubMedCrossRefGoogle Scholar
  9. 9.
    Wang, A.H.J., Quigley, G.J., Kolpak, F.J., Crawford, J.L., van Boom, J.H., van der Marel, G. and Rich, A.(1979) Nature 282, 680.PubMedCrossRefGoogle Scholar
  10. 10.
    Morgenegg, G., Celio, M.R., Malfoy, B., Leng, M. and Kuenzle, C.C. (1983) Nature 303, 540.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • Clive C. Kuenzle
    • 1
  1. 1.Institut für Pharmakologie und BiochemieUniversität Zürich-IrchelZürichSwitzerland

Personalised recommendations