DNA-Binding Proteins in Replicating and Mitotically Arrested Brain Neurons
Neurons of the cerebral cortex and the cerebellum of the rat appear to be excellently suited to study the signals mediating mitotic arrest in vivo. This is because the time course of neuronal differentiation is known exactly in both these parts of the brain and in this species. A decisive event in neuronal differentiation is the transition from proliferating precursor cells to non-dividing, terminally differentiating neurons. This takes place just about term in the cortex but only after birth in the cerebellum.
KeywordsMitotic Arrest Cerebellar Neuron Proliferate Precursor Cell Reductive Methylation Cerebral Cortex Neuron
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