Poly (ADP-Ribosylation) and DNA Topoisomerase I in Different Cell Lines

  • Ari M. Ferro
  • Larry H. Thompson
  • Baldomero M. Olivera
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 179)


With his discovery that the Escherichia coli chromosome was circular, John Cairns first pointed out the need for a swivel in DNA replication (1). In eukaryotes, type I DNA topoisomerase has the enzymatic properties necessary to serve as such a swivel. DNA replication would introduce positive supertwists ahead of the replication fork; DNA topoisomerase I has the capacity to unwind such positively supertwisted DNA (2, 3). For this reason, a role for topoisomerase I in replication has been suggested by many workers (2, 3). Recent biological and phenomenological data have also led to the suggestion that type I DNA topoisomerase may be involved in catalyzing DNA strand exchange under certain conditions (4). The mechanisms by which the activity of such a potentially important enzyme may be modulated are of obvious interest.


Yeast Extract Chinese Hamster Ovary Cell Replication Fork Sister Chromatid Exchange Strand Exchange 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • Ari M. Ferro
    • 1
  • Larry H. Thompson
    • 2
  • Baldomero M. Olivera
    • 1
  1. 1.Department of BiologyUniversity of UtahSalt Lake CityUSA
  2. 2.Lawrence Livermore National LaboratoryLivermoreUSA

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