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Effects of Various Hormones on the Pituitary-Adrenal Axis

  • Julian I. Kitay
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 54)

Abstract

Most discussions of the mechanisms concerned with regulation of the pituitary-adrenal axis consider only components intrinsic to the system. Current understanding of the essential factors involved may be summarized briefly as follows. Stimulatory and inhibitory inputs from a variety of sources converge on centers in the basal hypothalamus. These signals result in stimulation (or inhibition) of corticotropin releasing factor (CRF) secretion from the median eminence. CRF is transported via the hypothalami co-hypophyseal portal system to the anterior pituitary gland and stimulates adrenocorticotropic hormone (ACTH) secretion; ACTH in turn, stimulates adrenal corticosteroid secretion. Corticosterone, the principle glucocorticoid hormone in the rat, is bound in plasma to corticosterone binding globulin (CBG); however, a fraction remains unbound in equilibrium with the bound portion. The liver clears circulating corticosteroids and metabolizes them, by reduction and conjugation, to inactive compounds which are excreted.

Keywords

Reductase Activity Pineal Gland Corticotropin Release Factor Gonadal Hormone Estradiol Replacement 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1975

Authors and Affiliations

  • Julian I. Kitay
    • 1
  1. 1.Division of Endocrinology and Metabolism, Departments of Internal Medicine and Physiology, School of MedicineUniversity of VirginiaCharlottesvilleUSA

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