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An Analysis of the Pineal Hydroxyindole-O-Methyl Transferase Rhythm During the Estrous Cycle of the Rat

  • E. P. Wallen
  • J. M. Yochim
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 54)

Abstract

For the past few years our laboratory has been interested in the relationship between pineal gland rhythmicity and reproductive function in the rat. As an index of pineal rhythmicity we followed the diurnal variations in hydroxyindole-O-methyl transferase (HIOMT), the enzyme which forms melatonin, one of the pineal’s antigonadotropic hormones. We have interpreted the effects of endocrine and environmental manipulation in terms of changes in a mixed-wave equation.

Keywords

Pineal Gland Estrous Cycle Ovarian Hormone Thetical Rhythm Continuous Darkness 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Axelrod, J., Wurtman, R. J. and Snyder, S. H. (1965). Control of hydroxyindole-O-methyltransferase activity in the rat pineal gland by environmental lighting. J. Biol. Chem. 240, 949–954.PubMedGoogle Scholar
  2. Halberg, F. (1960). Temporal coordination of physiologic function. Cold Spring Harbor Symp. Quant. Biol. 25, 289–310.PubMedCrossRefGoogle Scholar
  3. Wallen, E. P. and Yochim, J. M. (1973a). Rhythmic function of pineal hydroxyindole-O-methyltransferase during the estrous cycle: an analysis. Biol. Reprod. In press.Google Scholar
  4. Wallen, E. P. and Yochim, J. M. (1973b). Pineal HIOMT activity in the rat: effect of ovariectomy and hormone replacement. Biol. Reprod. In press.Google Scholar
  5. Yochim, J. M. and Wallen, E. P. (1973a). Function of the pineal gland of the rat during progestation: alterations in HIOMT rhythmicity. Biol. Reprod. In press.Google Scholar
  6. Yochim, J. M. and Wallen, E. P. (1973b). HIOMT activity in the pineal gland of the female rat: effects of light. Biol. Reprod. In press.Google Scholar

Copyright information

© Plenum Press, New York 1975

Authors and Affiliations

  • E. P. Wallen
    • 1
  • J. M. Yochim
    • 1
  1. 1.Department of Physiology and Cell BiologyUniversity of KansasLawrenceUSA

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