Achondroplasia: An Altered GH Control in Post-Receptorial Chondrocyte Cell Sites?
For a contribution to the understanding of the pathophysiology of achondroplasia in its widely variable picture and prognosis (neurological complications and adult stature) (1,2), in 1980 we began to study a group of 9 achondroplastic children. Our attention was attracted by the constant presence of precocious hydrocephalus. — always documented by routine skull X-rays (Fig. 1) and cranial CT scan (Fig. 2) — which often appears from the first year of life and sometimes evolves in a progressive manner.
KeywordsVariable Picture Stimulate Proteoglycan Synthesis Tanner Method Achondroplastic Child Routine Skull
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