Achondroplasia: An Altered GH Control in Post-Receptorial Chondrocyte Cell Sites?

  • P. Borrelli
  • P. del Balzo
  • E. Neri
Part of the Basic Life Sciences book series (BLSC, volume 48)


For a contribution to the understanding of the pathophysiology of achondroplasia in its widely variable picture and prognosis (neurological complications and adult stature) (1,2), in 1980 we began to study a group of 9 achondroplastic children. Our attention was attracted by the constant presence of precocious hydrocephalus. — always documented by routine skull X-rays (Fig. 1) and cranial CT scan (Fig. 2) — which often appears from the first year of life and sometimes evolves in a progressive manner.


Variable Picture Stimulate Proteoglycan Synthesis Tanner Method Achondroplastic Child Routine Skull 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • P. Borrelli
    • 1
  • P. del Balzo
    • 1
  • E. Neri
    • 1
    • 2
  1. 1.Endocrinology DepartmentBambino Gesù Hospital, Research InstituteRomeItaly
  2. 2.Paediatric Consultancy UnitBambino Gesù Hospital, Research InstituteRomeItaly

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