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Achondroplasia: An Altered GH Control in Post-Receptorial Chondrocyte Cell Sites?

  • P. Borrelli
  • P. del Balzo
  • E. Neri
Part of the Basic Life Sciences book series (BLSC, volume 48)

Abstract

For a contribution to the understanding of the pathophysiology of achondroplasia in its widely variable picture and prognosis (neurological complications and adult stature) (1,2), in 1980 we began to study a group of 9 achondroplastic children. Our attention was attracted by the constant presence of precocious hydrocephalus. — always documented by routine skull X-rays (Fig. 1) and cranial CT scan (Fig. 2) — which often appears from the first year of life and sometimes evolves in a progressive manner.

Keywords

Variable Picture Stimulate Proteoglycan Synthesis Tanner Method Achondroplastic Child Routine Skull 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    W. A. Horton et al., Standard growth curves for achondroplasia, J. of Pediatrics, 93, 3:435 (1978).CrossRefGoogle Scholar
  2. 2.
    J. T. Hecht et al., Long term neurological sequelae in achondroplasia, Eur. J. Pediatr., 143:58 (1984).PubMedCrossRefGoogle Scholar
  3. 3.
    L. E. Underwood et al., Paracrine functions of somatomedins. Clinics in Endocrinol. Metab., 15,1:59:77 (1986).Google Scholar
  4. 4.
    H. D. Mosier, Jr., The control of catch-up growth, m: “Pediatric Endocrinology 1986,” R. Illig and H. K. D. Visser, eds., p. 1–7.Google Scholar
  5. 5.
    H. D. Mosier et al., Cartilage metabolism during growth retardation following irradiation of head of neonatal rat, Proc. Soc. Exp. Biol. Med., 172:99 (1983b).PubMedGoogle Scholar
  6. 6.
    R. Wynne-Davies et al., Achondroplasia and hypochondroplasia, J. of Bone and Joint Surgery, 63–B,4:508 (1981).Google Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • P. Borrelli
    • 1
  • P. del Balzo
    • 1
  • E. Neri
    • 1
    • 2
  1. 1.Endocrinology DepartmentBambino Gesù Hospital, Research InstituteRomeItaly
  2. 2.Paediatric Consultancy UnitBambino Gesù Hospital, Research InstituteRomeItaly

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