Achondroplastic Mice: Morphological Investigations of Epiphyseal Cartilage and Bone

  • Ermanno Bonucci
  • Benedetto Nicoletti
Part of the Basic Life Sciences book series (BLSC, volume 48)


Achondroplasia has been repeatedly described in animals. The cn/cn mice (8) are characterized by a type of dwarfism which is associated with normal levels of somatotropic hormone (6) and with skeletal abnormalities very similar to those which characterize human achondroplasia. Consequently, the cn/cn mice represent a useful model for studying human achondroplasia.


Hypertrophic Chondrocytes Matrix Vesicle Alcian Blue Staining Epiphyseal Cartilage Calcification Process 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Ermanno Bonucci
    • 1
  • Benedetto Nicoletti
    • 2
  1. 1.Dept. of Human Biopathology, Pathological Anatomy Section“La Sapienza” UniversityRomeItaly
  2. 2.Dept. of Public Health and Cell Biology IIUniversity of RomeRomeItaly

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