Achondroplastic Mice: Morphological Investigations of Epiphyseal Cartilage and Bone
Achondroplasia has been repeatedly described in animals. The cn/cn mice (8) are characterized by a type of dwarfism which is associated with normal levels of somatotropic hormone (6) and with skeletal abnormalities very similar to those which characterize human achondroplasia. Consequently, the cn/cn mice represent a useful model for studying human achondroplasia.
KeywordsHypertrophic Chondrocytes Matrix Vesicle Alcian Blue Staining Epiphyseal Cartilage Calcification Process
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