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Growth Plate Cartilage Studies in Achondroplasia

  • William A. Horton
  • O. Jean Hood
  • Mirta A. Machado
  • Dianna Campbell
Part of the Basic Life Sciences book series (BLSC, volume 48)

Abstract

Achondroplasia is the most common of the inherited bone dysplasias in man. It is well defined clinically, radiographically and genetically (1, 2). Although its pathogenesis is thought to involve defective endochondral ossification, the specific way in which this occurs is not known. Previous studies of the growth plate in achondroplasia have suggested that the architecture of the growth plate may be mildly abnormal and that there may be abnormalities of extracellular matrix constituents including cartilage collagen and proteoglycan (3, 4). To further explore this issue we have investigated growth plate tissue from 7 patients with heterozygous achondroplasia and 2 patients with homozygous achondroplasia by a combination of biochemical, immunohistochemical, morphometric and ultrastructural methods.

Keywords

Growth Plate Endochondral Ossification Hypertrophic Chondrocytes Proliferative Zone Cyanogen Bromide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • William A. Horton
    • 1
  • O. Jean Hood
    • 1
  • Mirta A. Machado
    • 1
  • Dianna Campbell
    • 1
  1. 1.Dept. of PediatricsUniv. of Texas Health Science CenterHoustonUSA

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