Gene Expression in the Early Mouse Embryo and Cultured Cells
Development of the early mouse embryo has been described in great detail and provides the basis for studies in elucidating how cellular differentiation processes are programmed and coordinated during mammalian development. To this end, it has been important to isolate and characterize cell- and tissue-specific markers, genes and their products, which are expressed in early mouse embryogenesis. Indeed, a number of such markers have been identified and some of them can be used to distinguish the appearance of the very first differentiated cell types. An understanding of how and why these markers are selectively expressed during development, it seems, is a first step in finding out the molecular basis for differentiation processes.
KeywordsEmbryonic Stem Cell Line Endoderm Cell Embryonal Carcinoma Cell Basement Membrane Component Visceral Endoderm
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