Application of Mass Spectrometry to Forensic Toxicology
The use of mass spectrometry in forensic toxicology to detect acidic and neutral drugs is discussed. The speed and versatility of the mass spectrometer make it suitable for detecting these drugs and their metabolites. The advantages of using this method as an analytical tool include the ability to identify drugs for which good chemical tests are lacking, the use of small samples, and the saving of time by direct determination of acidic and neutral fractions without further purification. The mass spectra of these drugs can be obtained at volatilization temperatures below those necessary for normally-occurring interfering tissue impurities.
KeywordsMass Peak Liver Extract Neutral Compound Tissue Impurity Forensic Toxicology
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