Optimization of Analytical Methods Using Designed Experiments

  • R. K. Skogerboe
Part of the Developments in Applied Spectroscopy book series (DAIS, volume 6)


To develop any analytical method, answers to the following questions are required:
  1. 1.

    What variables influence the measurement?

  2. 2.

    What are the best conditions for making the measurement?

  3. 3.

    What degree of regulation is required for each of the respective variables?


Because most analyses are affected by several variables, some of which may be interdependent, obtaining definitive answers via classical methods of experimentation is both time-consuming and complex, if not impossible. Experimental designs have been developed, however, which are capable of efficiently providing objective answers. The basic concepts of the design and analysis of such optimization experiments will be discussed with graphic illustrations and a minimum of mathematics. Applications of these methods to various spectrochemical optimization problems will be presented.


Central Composite Design Steep Ascent Star Point Flame Region Objective Answer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Chicago Section of the Society for Applied Spectroscopy 1968

Authors and Affiliations

  • R. K. Skogerboe
    • 1
  1. 1.Chemistry DepartmentCornell UniversityIthacaUSA

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