Optimization of Analytical Methods Using Designed Experiments
What variables influence the measurement?
What are the best conditions for making the measurement?
What degree of regulation is required for each of the respective variables?
Because most analyses are affected by several variables, some of which may be interdependent, obtaining definitive answers via classical methods of experimentation is both time-consuming and complex, if not impossible. Experimental designs have been developed, however, which are capable of efficiently providing objective answers. The basic concepts of the design and analysis of such optimization experiments will be discussed with graphic illustrations and a minimum of mathematics. Applications of these methods to various spectrochemical optimization problems will be presented.
KeywordsCentral Composite Design Steep Ascent Star Point Flame Region Objective Answer
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