Hypersensitive Cholinergic Functioning in Primary Affective Illness

  • N. Sitaram
  • A. M. Moore
  • C. Vanskiver
  • J. Blendy
  • J. I. NurnbergerJr.
  • E. S. Gershon
  • J. C. Gillin
Part of the Advances in Behavioral Biology book series (ABBI, volume 25)


Primary affective illness is characterized by two distinct mood states, depression and mania. While depressed, patients typically show changes in mood (sadness, crying, feelings of worthlessness and hopelessness), physical activity (anergy, fatigue, psychomotor retardation),and sleep changes (short fragmented sleep, with decreased latency to the onset of the first REM period (8,18). While manic, patients are euphoric, hyperactive and hyposomniac.


Postpartum Depression Affective Illness Hypothermic Effect Sleep Change Baseline Pupillary Diameter 
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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • N. Sitaram
    • 1
  • A. M. Moore
    • 1
  • C. Vanskiver
    • 1
  • J. Blendy
    • 1
  • J. I. NurnbergerJr.
    • 2
  • E. S. Gershon
    • 2
  • J. C. Gillin
    • 1
  1. 1.Unit on Sleep StudiesNational Institutes of HealthBethesdaUSA
  2. 2.Unit on Sleep Studies, Section on Psychogenetics Biological Psychiatry Branch, National Institute of Mental HealthNational Institutes of HealthBethesdaUSA

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