Multiple Mechanisms in Ganglionic Transmission

  • N. J. Dun
  • A. G. Karczmar
Part of the Advances in Behavioral Biology book series (ABBI, volume 25)


Transmission in sympathetic ganglia is complex; in addition to the fast excitatory postsynaptic potential (f-epsp) which represents a primary synaptic pathway of the ganglia, there are several slow synaptic potentials, both excitatory and inhibitory that may serve to modulate the primary transmission; these include slow excitatory and late slow excitatory postsynaptic potentials (s-epsp and ls-epsp respectively) and slow inhibitory postsynaptic potential (s-ipsp) (3,14,18,19,23). Ganglionic transmission is also a multitransmitter phenomenon. There is now evidence that in addition to the classical transmitter, acetylcholine (ACh), a number of other substances may serve as transmitters or modulators in the ganglia. In recent years, immunohistofluorescent techniques have demonstrated the presence of various peptides, such as substance P or a related peptide, and enkephalins or enkephalin-like substances, in peripheral media (cf. 28). We present here some of our findings indicating that substance P and enkephalins may indeed participate in ganglionic transmission.


Sympathetic Ganglion Superior Cervical Ganglion Primary Transmission Opiate Antagonist Slow Potential 


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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • N. J. Dun
    • 1
  • A. G. Karczmar
    • 1
  1. 1.Department of PharmacologyLoyola University Stritch School of MedicineMaywoodUSA

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