Clinical Trials with Choline and 4-Aminopyridine in Huntington’S Chorea

  • S. M. Aquilonius
  • S. A. Eckernas
Part of the Advances in Behavioral Biology book series (ABBI, volume 25)


The rare hereditary form of chorea described by George Huntington in 1872 (23) has, especially during the past decade, been the object of intense research by neuroscientists using the principal approaches illustrated in Fig. 1. The figure also includes the different reasons to suggest a striatal cholinergic hypofunction playing one pathophysiological role in the disease. This field of research has recently been reviewed in detail (8).


Tardive Dyskinesia Kainic Acid Friedreich Ataxia Principal Approach Choline Acetyl Transferase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Agoston, S., van Weerden, T., Westra, P. and Broekert, A. (1978): Brit. J. Anesthesiol. 50:383–385.CrossRefGoogle Scholar
  2. 2.
    Anden, N.E. and Leander, S. (1979): J. Neural Trans. 44:1–12.CrossRefGoogle Scholar
  3. 3.
    Aquilonius, S.M. and Sjostrom, R. (1971): Life Sci. 10:405–414CrossRefGoogle Scholar
  4. 4.
    Aquilonius, S.M., Nystrom, B., Schuberth, J. and Sundwall, A. (1972): J. Neurol. Neurosurg. Psychiat. 15:720–725.CrossRefGoogle Scholar
  5. 5.
    Aquilonius, S.M. and Eckernas, S.A. (1975): New Engl. J. Med. 293:1105–1106.Google Scholar
  6. 6.
    Aquilonius, S.M., Eckernas, S.A. and Sundwall, A. (1975): J. Neurol. Neurosurg. Psychiat. 38:669–677.CrossRefGoogle Scholar
  7. 7.
    Aquilonius, S.M. and Eckernas, S.A. (1977): Neurology 27: 887–889.CrossRefGoogle Scholar
  8. 8.
    Aquilonius, S.M. (1978): Acta Neurol. Scand. 57 (Suppl. 67): 115–122.Google Scholar
  9. 9.
    Barbeau, A. (1978): J. Canad. Sci. Neurol. 5:157–160.Google Scholar
  10. 10.
    Booij, L.H.D.J., Miller, R.D. and Crul, J.F. (1978): Anaesthesiol. Analg. 57:316–321.Google Scholar
  11. 11.
    Boyd, W.D., Graham-White, J., Blackwood, G., Glen, I. and McQueen, J. (1977): Lancet 2 711.CrossRefGoogle Scholar
  12. 12.
    Cohen, E.L. and Wurtman, R.J. (1975): Life Sci. 16:1095–1102.CrossRefGoogle Scholar
  13. 13.
    Cohen, E.L. and Wurtman, R.J. (1976): Science 191:561–562.CrossRefGoogle Scholar
  14. 14.
    Coyle, J.T. and Schwarcz, R. (1976): Nature 263:244–246.CrossRefGoogle Scholar
  15. 15.
    Davis, K.L., Hollister, L.E., Barchas, J.D. and Berger, P.A. (1976): Life Sci. 19:1507–1516.CrossRefGoogle Scholar
  16. 16.
    Davis, K.L. and Berger, P.A. (1978): Biol. Psychiat. 13:23–49.Google Scholar
  17. 17.
    Eckernas, S.A., Sahistrom, L. and Aquilonius, S.M. (1977): Acta Physiol. Scand. 101:404–410.CrossRefGoogle Scholar
  18. 18.
    Etienne, P., Gauthier, S., Johnson, G., Collier, B., Mendis, T., Dastoor, D., Cole, M. and Muller, H.F. (1978): Lancet 1 508–509.CrossRefGoogle Scholar
  19. 19.
    Flentge, F. and Van den Berg, C.J. (1979): J. Neurochem. 32: 1331–1333.CrossRefGoogle Scholar
  20. 20.
    Growden, J.H., Cohen, E.L. and Wurtman, R.J. (1977): Ann. Neurol. 1: 418–422.CrossRefGoogle Scholar
  21. 21.
    Haubrich, D.R., Wang, P.F., Clody, D.E. and Wedeking, P.W. (1975): Life Sci. 17:975–980.CrossRefGoogle Scholar
  22. 22.
    Hirsch, M.J., Growden, J.H. and Wurtman, R.J. (1977): Neurology 27:391.Google Scholar
  23. 23.
    Huntington, G. (1872): Med. Surg. Rept., Philadelphia, 317–321.Google Scholar
  24. 24.
    Johns, A., Golko, D.S., Lauzon, P.A. and Paton, D.M. (1976): Eur. J. Pharmacol. 38:71–78.CrossRefGoogle Scholar
  25. 25.
    Klawans, H.Z. and Rubovits, R. (1972): Neurology 22:107–116.CrossRefGoogle Scholar
  26. 26.
    Ladinsky, H., Consolo, S. and Pugnetti, P. (1979): In Nutrition and the Brain, (eds) A. Barbeau, J.H. Growden and R.J. Wurtman, Raven Press, New York.Google Scholar
  27. 27.
    Legg, N.J. (1978): Brit. Med. J. 2:1403.CrossRefGoogle Scholar
  28. 28.
    Legg, N.J. (1979): Brit. Med. J. 2:133.CrossRefGoogle Scholar
  29. 29.
    Livingstone, I.R. and Mastaglia, F.L. (1979): Brit, Med. J. 2:939.CrossRefGoogle Scholar
  30. 30.
    Lundh, H., Nilsson, O. and Rosen, I. (1977): J. Neurol. Neurosurg. Psychiat. 40:1109–1112.CrossRefGoogle Scholar
  31. 31.
    Lundh, H. and Thesleff, S. (1977): Eur. J. Pharmacol. 42:411–412.CrossRefGoogle Scholar
  32. 32.
    Mason, S.T. and Fibiger, H.C. (1979): Neuropharmacology 18:403–407.CrossRefGoogle Scholar
  33. 33.
    Mohs, R.C., Davis, K.L., Tinklenberg, J.R., Hollister, L.E., Yesavage, J.A. and Kopell, B.S. (1979): Amer. J. Psychiat. 136:1275–1277.Google Scholar
  34. 34.
    Nutt, J.G., Rosin, A. and Chase, T.N. (1978): Neurology 28: 1061–1064.CrossRefGoogle Scholar
  35. 35.
    Pedata, F., Wieraszko, A. and Pepeu, G. (1977): Pharmacol. Res. Commun. 9:755–761.CrossRefGoogle Scholar
  36. 36.
    Renvoize, E.B. and Jerram, T. (1979): New Engl. J. Med. 2:330.Google Scholar
  37. 37.
    Signoret, J.L., Whiteley A. and L’Hermite, F. (1978); Lancet 2:837.CrossRefGoogle Scholar
  38. 38.
    Wastek, G.J. and Yamamura, H.I. (1978); Molee. Pharmacol. 14:768–780.Google Scholar
  39. 39.
    Wecker, L. and Schmidt, D.E. (1979): Life Sci. 25:375–384.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • S. M. Aquilonius
    • 1
  • S. A. Eckernas
    • 1
  1. 1.Department of NeurologyUniversity HospitalUppsalaSweden

Personalised recommendations