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Clinical Trials with Choline and 4-Aminopyridine in Huntington’S Chorea

  • Chapter
Cholinergic Mechanisms

Part of the book series: Advances in Behavioral Biology ((ABBI,volume 25))

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Abstract

The rare hereditary form of chorea described by George Huntington in 1872 (23) has, especially during the past decade, been the object of intense research by neuroscientists using the principal approaches illustrated in Fig. 1. The figure also includes the different reasons to suggest a striatal cholinergic hypofunction playing one pathophysiological role in the disease. This field of research has recently been reviewed in detail (8).

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Author information

Authors and Affiliations

  1. Department of Neurology, University Hospital, S-750 14, Uppsala, Sweden

    S. M. Aquilonius & S. A. Eckernas

Authors
  1. S. M. Aquilonius
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  2. S. A. Eckernas
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Editor information

Editors and Affiliations

  1. Institute of Pharmacology, University of Florence, Florence, Italy

    Giancarlo Pepeu

  2. Mario Negri Institute for Pharmacological Research, Milan, Italy

    Herbert Ladinsky

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© 1981 Plenum Press, New York

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Aquilonius, S.M., Eckernas, S.A. (1981). Clinical Trials with Choline and 4-Aminopyridine in Huntington’S Chorea. In: Pepeu, G., Ladinsky, H. (eds) Cholinergic Mechanisms. Advances in Behavioral Biology, vol 25. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8643-8_86

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  • DOI: https://doi.org/10.1007/978-1-4684-8643-8_86

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-8645-2

  • Online ISBN: 978-1-4684-8643-8

  • eBook Packages: Springer Book Archive

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