Abstract
Previous reports from this laboratory (9) showed a differential recovery of various forms of acetylcholinesterase (AChE) of the rat brain after poisoning by DFP, the recovery being particularly rapid for medium molecular weight forms, and the phenomenon markedly pronounced in the striatum (8). It is well known that DFP and paraoxon cause substantially the same symptoms in the early phase of poisoning although differing in their chemical structure, which determines the type of phosphorylated AChE formed (diisopropyl- and diethylphos-phoryl-, respectively) and the rate of subsequent recovery in vivo and in vitro (for references see 1,4,7,12).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bignami, G., Rosic, N., Michalek, H., Milosevic, M. and Gatti, G.L. (1975): IN Behavioral Toxicology (eds) B. Weiss and V.G. Laties, Plenum Press, New York, pp. 155–215.
Bisso, G.M., Nemesio, R. and Michalek, H. (1980): IN A Multi-disciplinary Approach to Brain Development (eds) C. Di Benedetta, R. Balazs, G. Gombos and G. Porcellati, Elsevier-North-Holland, Amsterdam, pp. 235–236.
Cisson, CM. and Wilson, B.W. (1977): Biochem. Pharmacol. 26:1955–1960.
Cohen, J.A. and Oosterbaan, R.A. (1963): IN Handbuch der Experimentellen Pharmakologie, Vol. 15 (ed) G.B. Koelle, Springer, Berlin, pp. 299–373.
Davis, G.A. and Agranoff, B.W. (1968): Nature 20:277–280.
Ellman, G.L., Courtney, K.D., Andres, V. Jr. and Featherstone, R.M. (1961): Biochem. Pharmacol. 788–95.
Main, A.R. (1979): Pharmacol. Ther. 6:579–628.
Meneguz, A., Bisso, G.M. and Michalek, H. (1981): Clin. Toxicol. (in press).
Michalek, H., Meneguz, A., Bisso, G.M., Carro-Ciampi, G., Gatti, G.L. and Bignami, G. (1979): IN Advances in Pharmacology and Therapeutics, Vol. 9 (ed) Y. Cohen, Pergamon Press, Oxford, pp. 187–201.
Niemierko, S. and Skangiel-Kramska, J. (1976): Bull. Acad. Pol. Sci. (Biol) 24:445–448.
Rieger, F., Faivre Bauman, A., Benda, P. and Vigny, M. (1976): J. Neurochem. 27:1059–1063.
Usdin, E. (1970): IN Anticholinesterase Agents (ed) A.G. Karczmar, Pergamon Press, Oxford, pp. 47–354.
Wilson, B.W. and Walker, CR. (1974): Proc. Nat. Acad. Sci. 7:3194–3198.
Yaksh, T.L., Filbert, M.G., Harris, L.W. and Yamamura, H.I. (1975): J. Neurochem. 25:853–860.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1981 Plenum Press, New York
About this chapter
Cite this chapter
Michalek, H., Bisso, G.M., Meneguz, A. (1981). Comparative Studies on Rat Brain Soluble Acetylcholinesterase and Its Molecular Forms during Intoxication by DFP and Paraoxon. In: Pepeu, G., Ladinsky, H. (eds) Cholinergic Mechanisms. Advances in Behavioral Biology, vol 25. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8643-8_84
Download citation
DOI: https://doi.org/10.1007/978-1-4684-8643-8_84
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-8645-2
Online ISBN: 978-1-4684-8643-8
eBook Packages: Springer Book Archive