Do Gangliosides Affect the Recovery of Cholinergic Enzymes of Rats after Septal Lesions?

  • M. Wojcik
  • J. Ulas
Part of the Advances in Behavioral Biology book series (ABBI, volume 25)


A partial progressive recovery of acetylcholinesterase (AChE) and choline acetyltransferase (CAT) activities has been shown after extensive medioventral septal lesions (7). It was suggested that the recovery of cholinergic enzymes activity could be due to sprouting of cholinergic nerve terminals from the intact part of the septum. Since gangliosides can stimulate the regeneration and re-innervation processes of cholinergic fibers in the peripheral nervous system (2), it seemed interesting to investigate the influence of gangliosides on the activity of cholinergic enzymes in the hippocampus of rats after medioventral septal lesions.


AChE Activity Septal Lesion Nucleus Dorsalis Cholinergic Fiber Choline Acetyl Transferase 
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  1. 1.
    Bonetti, A.C., Benvegnu, D., Leon, A., Facci, L., Toffano, C. and Tettamenti, G. (1979): IN Proc. Fifth Int. Symp. Glyco-conjugates, Kiel, pp. 576–579.Google Scholar
  2. 2.
    Ceccarelli, B., Aporti, F, and Finesso, M. (1978): IN Ganglio-side Function (eds) G. Porcellati, R. Ceccarelli and G. Tettamanti, Plenum Press, New York, pp. 275–293.Google Scholar
  3. 3.
    Cumar, F.A., Maggio, B. and Caputto, R. (1978): Biochem. Biophys. Res. Commun. 84:65–69.CrossRefGoogle Scholar
  4. 4.
    Ellman, G.L., Courtney, K.D., Anders, V. and Featherstone, R. (1961): Biochem. Pharmacol. 7:88–95.CrossRefGoogle Scholar
  5. 5.
    Fonnum, F. (1975): J. Neurochem. 24:407–409.CrossRefGoogle Scholar
  6. 6.
    Lowry, O.H., Rosebrough, J.J., Farr, A.L. and Randall, R.J. (1951): J. Biol. Chem. 193:265–275.Google Scholar
  7. 7.
    Oderfeld-Nowak, B., Potempska, A. and Oderfeld, J. (1977): Neuroscience 2:641–648.CrossRefGoogle Scholar
  8. 8.
    Orlando, P., Cocciante, G., Ippolito, G., Massari, P., Roberti, S. and Tettamanti, G. (1979): Pharmacol. Res. Commun. 11: 759–773.CrossRefGoogle Scholar
  9. 9.
    Purpura, D.P. and Baker, H.J. (1978): Brain Res. 143:13–15.CrossRefGoogle Scholar
  10. 10.
    Srebro, B., Oderfeld-Nowak, B., Klodos, I., Dobrowska, J. and Narkiewicz, O. (1973): Life Sci. 12:261–270.CrossRefGoogle Scholar
  11. 11.
    Toffano, G., Benvegnu, D., Bonetti, A.C., Facci, L., Leon, A., Orlando, P. and Tettamanti, G. (1980): (in press).Google Scholar
  12. 12.
    Yamamawa, T. and Nagai, Y. (1978): TIBS 3:128.Google Scholar

Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • M. Wojcik
    • 1
  • J. Ulas
    • 1
  1. 1.Laboratory of Neurochemistry Department of Biochemistry of Nervous System and MuscleNencki Institute of Experimental BiologyWarsawPoland

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