Do Gangliosides Affect the Recovery of Cholinergic Enzymes of Rats after Septal Lesions?
A partial progressive recovery of acetylcholinesterase (AChE) and choline acetyltransferase (CAT) activities has been shown after extensive medioventral septal lesions (7). It was suggested that the recovery of cholinergic enzymes activity could be due to sprouting of cholinergic nerve terminals from the intact part of the septum. Since gangliosides can stimulate the regeneration and re-innervation processes of cholinergic fibers in the peripheral nervous system (2), it seemed interesting to investigate the influence of gangliosides on the activity of cholinergic enzymes in the hippocampus of rats after medioventral septal lesions.
KeywordsAChE Activity Septal Lesion Nucleus Dorsalis Cholinergic Fiber Choline Acetyl Transferase
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