On Modulation of Cerebral Cholinergic Mechanisms by Endogenous Indoleamines and their Derivatives

  • B. Oderfeld-Nowak
  • M. H. Aprison
Part of the Advances in Behavioral Biology book series (ABBI, volume 25)


Since the early 1960s, a few investigators, including one of the present authors, began to point out in the literature that due to the complexity of the CNS, the probability is extremely great that several neurotransmitter systems or neurotransmitter-modulator systems are involved in the various functional illnesses rather than a single system (1,2). Further, one could envisage the possibility that changes in excitation or inhibition at one or more synapses could affect neurons further down a neuronal pathway utilized by a living organism in emitting specific types of responses (3). The malfunction of several of these synapses could result in directly imbalancing the neuronal system in which the pathway normally plays an important role. Thus, the “problem” at the end of an important common pathway could be due to one or more different transmitter or modulator defects in the input pathways (5,28). Therefore, it is not surprising that recently the concept was again enunciated, that a number of important functions of the brain result from a balance between two or more neuroregulators (7, 13). The full impact of these concepts a) provides a basis to explain why the 1-drug therapy often used does not provide a universal cure and hence may not be the method of choice in the future (3,7,13), and b) forms the basis of several newer hypotheses to explain psychiatric disorders. Certainly clarifying as well as identifying the specific malfunctioning mechanisms or “lesions” within the CNS should provide a better method to facilitate the treatment (5, 6, 28).


High Performance Liquid Chromatography High Performance Liquid Chromatography AChE Activity High Performance Liquid Chromatography Chromatogram Inhibit AChE Activity 
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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • B. Oderfeld-Nowak
    • 2
  • M. H. Aprison
    • 1
  1. 1.The Institute of Psychiatric Research, Departments of Psychiatry and BiochemistryIndiana University School of MedicineIndianapolisUSA
  2. 2.Nencki Institute of Experimental BiologyPolish Academy of SciencesWarsawPoland

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