On Modulation of Cerebral Cholinergic Mechanisms by Endogenous Indoleamines and their Derivatives

  • B. Oderfeld-Nowak
  • M. H. Aprison
Part of the Advances in Behavioral Biology book series (ABBI, volume 25)


Since the early 1960s, a few investigators, including one of the present authors, began to point out in the literature that due to the complexity of the CNS, the probability is extremely great that several neurotransmitter systems or neurotransmitter-modulator systems are involved in the various functional illnesses rather than a single system (1,2). Further, one could envisage the possibility that changes in excitation or inhibition at one or more synapses could affect neurons further down a neuronal pathway utilized by a living organism in emitting specific types of responses (3). The malfunction of several of these synapses could result in directly imbalancing the neuronal system in which the pathway normally plays an important role. Thus, the “problem” at the end of an important common pathway could be due to one or more different transmitter or modulator defects in the input pathways (5,28). Therefore, it is not surprising that recently the concept was again enunciated, that a number of important functions of the brain result from a balance between two or more neuroregulators (7, 13). The full impact of these concepts a) provides a basis to explain why the 1-drug therapy often used does not provide a universal cure and hence may not be the method of choice in the future (3,7,13), and b) forms the basis of several newer hypotheses to explain psychiatric disorders. Certainly clarifying as well as identifying the specific malfunctioning mechanisms or “lesions” within the CNS should provide a better method to facilitate the treatment (5, 6, 28).


High Performance Liquid Chromatography High Performance Liquid Chromatography AChE Activity High Performance Liquid Chromatography Chromatogram Inhibit AChE Activity 


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  1. 1.
    Aprison, M.H. (1962): Recent Adv. Biol. Psychiat. 4:133–146.CrossRefGoogle Scholar
  2. 2.
    Aprison, M.H. (1965): IN Horizons in Neuropsychopharmacology (eds) W. Himwich and J. Schade, Elsevier, Amsterdam, pp. 48–80.CrossRefGoogle Scholar
  3. 3.
    Aprison, M.H. (1977): IN Neuroregulators and Psychiatric Disorders (eds) E. Usdin, D. Hamberg and J. Barchas, Oxford University Press, New York, pp. 381–390.Google Scholar
  4. 4.
    Aprison, M.H., Kariya, T., Hingten, J.N. and Toru, M. (1968): J. Neurochem. 15:1131–1139.CrossRefGoogle Scholar
  5. 5.
    Aprison, M.H. and Hingtgen, J.N. (1970): Int. Rev. Neurobiol. 13:325–341.CrossRefGoogle Scholar
  6. 6.
    Aprison, M.H. and Hingtgen, J.N. (1980): IN Serotonin- Current Current Aspects of Neurochemistry and Function (eds) B. Haber, S. Gabay, S. Alivisatos and M. Issidorides, New York, Plenum Press, New York (in press).Google Scholar
  7. 7.
    Barchas, J.D., Akil, H., Elliott, G.R., Holman, B. and Watson, S.J. (1978): Science 200:964–973.CrossRefGoogle Scholar
  8. 8.
    Barker, S.A., Harrison, R.E., Brown, G.B. and Christian, S.T. (1979): Biochem. Biophys. Res. Commun. 87:146–154.CrossRefGoogle Scholar
  9. 9.
    Boit, H.A. (1960): IN Ergebnisse der Alkaloid Chemis, Akademie Verlag, Berlin, p. 487.Google Scholar
  10. 10.
    Buckholtz, N.S. and Boggan, W.O. (1977): Life Sci. 20:2093–2100.CrossRefGoogle Scholar
  11. 11.
    Butcher, L.L., ed (1978): Cho1inergic-Monoaminergic Interactions in the Brain, Academic Press, New York.Google Scholar
  12. 12.
    Butcher, S.H., Butcher, L.L. and Cho, A.K. (1976): Life Sci. 18:733–744.CrossRefGoogle Scholar
  13. 13.
    Butcher, L.L. and Talbot, K. (1978): IN Cholinergic-Monoaminergic Interactions in the Brain (ed) L.L. Butcher, Academic Press, New York, pp. 3–22.Google Scholar
  14. 14.
    Daly, J.W., Jerina, D.M. and Witkop, B. (1972): Experientia 28:1129–1149.CrossRefGoogle Scholar
  15. 15.
    Euvrard, C., Javoy, F., Herbet, A. and Glowinski, J. (1977): Eur. J. Pharmacol. 41:281–289.CrossRefGoogle Scholar
  16. 16.
    Fonnum, F. (1969): Biochem. J. 115:465–472.Google Scholar
  17. 17.
    Fujimoto, D. (1976): FEBS Lett. 71:121–123.CrossRefGoogle Scholar
  18. 18.
    Fuller, R.W. (1976): Life Sci. 19:625–628.CrossRefGoogle Scholar
  19. 19.
    Gal, E.M. and Sherman, A.D. (1978): J. Neurochem. 30:607–613.CrossRefGoogle Scholar
  20. 20.
    Galli, A., Renzi, G., Bartolini, A., Bartolini, R. and Malmberg Aiello, P. (1980): Abst. Int. Symp. Choi. Mech. p.113.Google Scholar
  21. 21.
    Ghosal, S., Bhattacharya, S.K. and Mehta, R. (1972): J. Pharm. Sci. 61:808.CrossRefGoogle Scholar
  22. 22.
    Gilboa-Barber, N., Katz-Bergman, Y. and Pinsky, A. (1978): Experientia 34:992–993.CrossRefGoogle Scholar
  23. 23.
    Goldman, J.E. and Schwartz, J.H. (1974): J. Physiol. 242:61–76.Google Scholar
  24. 24.
    Guyenet, P., Euvrard, C., Javoy, F., Herbert, A. and Glowinski, J. (1977): Brain Res. 136:487–500.CrossRefGoogle Scholar
  25. 25.
    Hanley, M.R. and Cottrell, G.A. (1974): J. Pharm. Pharmacol 26:980.CrossRefGoogle Scholar
  26. 26.
    Hanley, M.R., Cottrell, G.A., Emson, P.C. and Fonnum, F. (1974) Nature 251:631–633.CrossRefGoogle Scholar
  27. 27.
    Haubrich, D.R. and Reid, W.D. (1972): J. Pharmacol. Exp. Ther. 181:19–27.Google Scholar
  28. 28.
    Hingtgen, J.N. and Aprison, M.H. (1976): IN Biology of Cholinergic Function (eds) A.M. Goldberg and I. Hanin, Rayen Press, New York, pp. 515–566.Google Scholar
  29. 29.
    Honecker, H. and Rommelspacher, H. (1978): N.-S. Arch. Exp. Path. Pharmakol. 305:135–141.CrossRefGoogle Scholar
  30. 30.
    Horn, A.S. (1973): J. Neurochem. 21:883–888.CrossRefGoogle Scholar
  31. 31.
    Horn, A.S. and Trace, R.C.A.M. (1974): Brit. J. Pharmacol. 51:399–403.CrossRefGoogle Scholar
  32. 32.
    Hsu, L.L. and Mandell, A.J. (1975): J. Neurochem. 24:631–636.Google Scholar
  33. 33.
    Javoy, F., Euvrard, C., Herbet, A., Bockaert, J. Enjalbert, A., Agid, Y. and Glowinski, J. (1977): N.-S. Arch. Exp. Path. Pharmakol. 297:233–239.CrossRefGoogle Scholar
  34. 34.
    Kellar, K.J., Elliott, G.R., Holman, R.B., Barchas, J.D. and Vernikos-Danellis, J. (1976): J. Pharmacol. Exp. Ther. 198: 619–625.Google Scholar
  35. 35.
    Main, A.R. (1976): In Biology of Cholinergic Function (eds) A. Goldberg, and I. Hanin, Raven Press, New York, pp. 269–353Google Scholar
  36. 36.
    Mandel, L.R., Rosegay, A., Walker, R.W., Vanden-Heuvel, W.J.A. and Rokach, J. (1974): Science 136:741–743.CrossRefGoogle Scholar
  37. 37.
    Michatek, H. (1973): Biochem. Pharmacol. 22:1067–1074.CrossRefGoogle Scholar
  38. 38.
    Mohammed, Y.S., Osman, M.Y. and Gabr, Y. (1975): Arz. Forsch. Drug Res. 25:1714–1715.Google Scholar
  39. 39.
    Nakagawa, M., Okajima, H. and Hino, T. (1977): J. Amer. Chem. Soc. 99:4424–4429.CrossRefGoogle Scholar
  40. 40.
    Nakagawa, M., Yoshikawa, K. and Hino, T. (1975): J. Amer. Chem. Soc. 97:6496–6501.CrossRefGoogle Scholar
  41. 41.
    Oderfeld-Nowak, B., Simon, J.R., Chang, L. and Aprison, M.H. (1979):Soc. Neurosci. Abst. 5:412.Google Scholar
  42. 42.
    Oderfeld-Nowak, B., Simon, J.R., Chang, L. and Aprison, M.H. (1980):Gen. Pharmacol. 11:37–45.CrossRefGoogle Scholar
  43. 43.
    Oderfeld-Nowak, B., Skup, M., Ulas, J. and Rommelspacher, H.(1980):Abst. 3rd Meet. ESN (in press).Google Scholar
  44. 44.
    Oommen, A., Balasubramanian, A.S. (1978): Biochem. Pharmacol. 27:891–895.CrossRefGoogle Scholar
  45. 45.
    Osborne, N.N. (1979): Trends Neurosci. .2:73–75.CrossRefGoogle Scholar
  46. 46.
    Pepeu, G., Garau, L. and Mulas, M.L. (1974): Adv. Biochem. Psychopharmacol. 10:247–252.Google Scholar
  47. 47.
    Reader, T.A., de Champlain, J. and Jasper, H. (1976): Brain Res. 111:95–108.CrossRefGoogle Scholar
  48. 48.
    Reader, T.A. (1978): Experientia 34:1586–1587.CrossRefGoogle Scholar
  49. 49.
    Reader, T.A., Ferron, A., Descarries, L. and Jasper, H.H. (1979):Brain Res. 160:217–229.CrossRefGoogle Scholar
  50. 50.
    Reader, T.A., Masse, P. and de Champlain, J. (1979): Brain Res. 177:499–513.CrossRefGoogle Scholar
  51. 51.
    Rommenspacher, H., Honecker, H., Barbey, C. and Meinke, B. (1980):N.S. Arch. Exp. Path. Pharmakol. (in press).Google Scholar
  52. 52.
    Rommelspacher, H., Strauss, S. and Lindemann, J. (1980): FEBS Lett. 109:209–212.CrossRefGoogle Scholar
  53. 53.
    Rommelspacher, H., Strauss, M. and Rehse, K. (1978): J. Neurochem. 30:1573–1578.CrossRefGoogle Scholar
  54. 54.
    Rommelspacher, H. and Subramanian, N. (1979): Eur. J. Pharmacol. 56:81–86.CrossRefGoogle Scholar
  55. 55.
    Roth, R.H. and Bunney, B.S. (1976): IN Biology of Cholinergic Function (eds) A. Goldberg and I. Hanin, Raven Press, New York, pp. 379–394.Google Scholar
  56. 56.
    Samanin, R., Quattrone, A., Peri, G., Ladinsky H. and Consolo, S. (1978): Brain Res. 151:73–82.CrossRefGoogle Scholar
  57. 57.
    Shoemaker, D.W., Cummins, J.T. and Bidder, T.G. (1978): Neuro-science 3:233–239.Google Scholar
  58. 58.
    Shoemaker, D.W., Cummins, J.T., Bidder, T.G., Boettger, H.G. and Evans, M. (1980): N.-S. Arch. Pharmacol. 319:227–230.CrossRefGoogle Scholar
  59. 59.
    Silver, A. (1974): The Biology of Cholinesterases. North-Holland Publ., Amsterdam, pp. 449–487.Google Scholar
  60. 60.
    Skup, M., Mouleshlova, N.S. and Oderfeld-Nowak, B. (1980):VII Meeting Polish Soc. Pharmacol. Abst. (in press).Google Scholar
  61. 61.
    Sobotka, H. and Antopol, W. (1937): Enzymologia 4:189–191.Google Scholar
  62. 62.
    Thomas, T.N., Buckholtz, N.S. and Zemp, J.W. (1979): Life Sci. 25:1435–1442.CrossRefGoogle Scholar
  63. 63.
    Tonini, G. (1955): Soc. Ital. Biol. Sper. 31:766–771.Google Scholar
  64. 64.
    Toru, M., Hingtgen, J.N. and Aprison, M.H. (1966): Life Sci. 5:181–189.CrossRefGoogle Scholar
  65. 65.
    Tuomisto, L. and Tuomisto, J. (1973): Arch. Pharmacol. 279:371–380.CrossRefGoogle Scholar
  66. 66.
    Vizi, E.S. (1979): Prog. Neurobiol. 12:181–290.CrossRefGoogle Scholar
  67. 67.
    Wiggs, J.W. and Aprison, M.H. (1961): Physiologist 4:134.Google Scholar
  68. 68.
    Wyatt, R.J., Erdelyi, E., DoAmaral, J.R., Elliot, G.R., Rensor J. and Barehas, J.D. (1975): Science 187:853–855.CrossRefGoogle Scholar
  69. 69.
    Zsigmond, E.K., Foldes, F.F. and Foldes, V.M. (1961): J. Neuro chem. 8:72–80.Google Scholar

Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • B. Oderfeld-Nowak
    • 2
  • M. H. Aprison
    • 1
  1. 1.The Institute of Psychiatric Research, Departments of Psychiatry and BiochemistryIndiana University School of MedicineIndianapolisUSA
  2. 2.Nencki Institute of Experimental BiologyPolish Academy of SciencesWarsawPoland

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