Cholinergic-Monoaminergic Interactions in Selected Regions of the Brain: Histochemical and Pharmacologic Analyses

  • L. L. Butcher
  • N. J. Woolf
  • A. Albanese
  • S. H. Butcher
Part of the Advances in Behavioral Biology book series (ABBI, volume 25)


The elucidation of neuronal circuitry has been a major goal in the neurosciences. Anatomic studies with radioactive amino acids and other neuronally transported substances such as horseradish peroxidase have focussed on possible relationships among different cell body groups in the central nervous system. In most of these experiments, however, neurochemical features of the relevant neural regions are usually not considered. Yet immense interest in certain of these neurochemicals exists, especially transmitters and related substances involved in neuronal communication processes, because of their obvious or apparent significance for functional neurobiology. In the present report we attempt to address the problem of transmitter neuroanatomy in three regions of the brain thought to be involved in cholinergic-monoaminergic interactions: the substantia nigra, corpus striatum and locus ceruleus.


Substantia Nigra Cholinergic Neuron Locus Ceruleus Selected Region Neuronal Somata 
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  1. 1.
    Agid, Y., Guyenet, P., Glowinski, J, Beaujouan J.C. and Javoy F. (1975): Brain Res. 86:488–492.CrossRefGoogle Scholar
  2. 2.
    Albanese A. and Butcher, L.L. (1979): Neurosci. Lett. 14:101–104.CrossRefGoogle Scholar
  3. 3.
    Albanese, A. and Butcher, L.L. (1980): Brain Res. Bull. 5:127–134.CrossRefGoogle Scholar
  4. 4.
    Atweh, S.F. and Kuhar, M.J. (1976): Eur. J. Pharmacol. 37:311–319.CrossRefGoogle Scholar
  5. 5.
    Butcher, L.L. (1977): Life Sci. 21:1207–1226.CrossRefGoogle Scholar
  6. 6.
    Butcher, L.L. (1977): IN Cholinergic Mechanisms and Psycho-pharmacology (ed) D.J. Jenden, Plenum Press, New York, pp. 93–124.Google Scholar
  7. 7.
    Butcher, L.L., ed (1978): Cholinerglc-monoaminergic Interactions in the Brain. Academic Press, New York.Google Scholar
  8. 8.
    Butcher, L.L. and Bilezikjian, L. (1975): Eur. J. Pharmacol.34:115–125.CrossRefGoogle Scholar
  9. 9.
    Butcher, L.L. and Marchand, R. (1978): Eur. J. Pharmacol. 52:415–417.CrossRefGoogle Scholar
  10. 10.
    Butcher, L.L. and Talbot, K. (1978): IN Cholinergic-monoaminergic Interactions in the Brain (ed) L.L. Butcher, Academic Press, New York, pp. 3–22.Google Scholar
  11. 11.
    Butcher, L.L. and Talbot, K. (1978): IN Cholinerglc-monoaminergic Interactions in the Brain (ed) L.L. Butcher, Academic Press, New York, pp. 25–95.Google Scholar
  12. 12.
    Butcher, L.L., Talbot, K. and Bilezikjian, L. (1975): J. Neural Transm. 37:127–153.CrossRefGoogle Scholar
  13. 13.
    Butcher, S.H. and Butcher, L.L. (1974): Brain Res. 71:167–171.CrossRefGoogle Scholar
  14. 14.
    Butcher, S.H. and Butcher, L.L. (1978): IN Cholinergic-Mono-aminergic Interactions in the Brain (ed) L.L. Butcher, Academic Press, New York, pp. 109–122.Google Scholar
  15. 15.
    Butcher, S.H., Butcher, L.L. and Cho, A.K. (1976): Life Sci. 18:733–744.CrossRefGoogle Scholar
  16. 16.
    Dahlstrom, A. and Fuxe, K. (1965): Acta Physiol. Scand. Suppl. 232:1–55.Google Scholar
  17. 17.
    de la Torre, J.C. and Surgeon, J.W. (1976): Histochemistry 49:81–93.CrossRefGoogle Scholar
  18. 18.
    Dross, K. and Kewitz, H. (1972): N.-S. Arch. Pharmacol. 274:91–106.Google Scholar
  19. 19.
    Emson, P.C. and Lindvall, O. (1979): Neuroscience 4:1–30.CrossRefGoogle Scholar
  20. 20.
    Garattini, S., Pujol, J.F. and Samanin, R., eds (1978): Interactions Between Putative Neurotransmitters in the Brain, Raven Press, New York.Google Scholar
  21. 21.
    Hattori, T. (1978): IN Cholinergic-Monoaminergic Interactions in the Brain (ed) L.L. Butcher, Academic Press, New York, pp. 97–108.Google Scholar
  22. 22.
    Hattori, T., Singh, V.K., McGeer, E.G. and McGeer, P.L. (1976):Brain Res. 102:164–173.CrossRefGoogle Scholar
  23. 23.
    Kimura, H., McGeer, E.G., McGeer, P.L. and Peng, F. (1979): Soc. Neurosci. Abst. 5:74.Google Scholar
  24. 24.
    Knight, D.P. (1970): Proc. Roy. Microscop. Soc. 6:26–27.Google Scholar
  25. 25.
    Koelle, G.B. (1954): J. Comp. Neurol. 100:211–235.CrossRefGoogle Scholar
  26. 26.
    Koelle, G.B. and Friedenwald, J.S. (1949): Proc. Soc. Exp. Biol. Med. 70:617–622.Google Scholar
  27. 27.
    Ladinsky, H., Consolo, S., Bianchi, S., Ghezzi, D. and Samanin, R. (1978): IN Interactions Between Putative Neuro-transmitters in the Brain (eds) S. Garattini, J.F. Pujol and R. Samanin, Raven Press, New York, pp. 3–21.Google Scholar
  28. 28.
    Lavyne, M.H., Koltun, W.A., Clement, J.A., Rosene, D.J., Pickren, K.S., Zervas, N.T. and Wurtman, R.J. (1978): Brain Res. 135:77–86.CrossRefGoogle Scholar
  29. 29.
    Lehmann, J. and Fibiger, H.C. (1979): Life Sci. 25:1939–1947.CrossRefGoogle Scholar
  30. 30.
    Levine, M.S., Hull, C.D., Garcia-Rill, E., Fuller, D.R.G. and Buchwald, N.A. (1978): IN Cholinergic-Monoaminergic Interactions in the Brain (ed) L.L. Butcher, Academic Press, New York, pp. 125–139.Google Scholar
  31. 31.
    McCulloch, J. and Harper, A.M. (1977): Amer. J. Physiol. 233:222–227.Google Scholar
  32. 32.
    McGeer, P.L., McGeer, E.G., Fibiger, H.C. and Wickson, V. (1971): Brain Res. 35:373–379.CrossRefGoogle Scholar
  33. 33.
    Nagy, J.I., Vincent, S.R. and Fibiger, H.C. (1978): Life Sci. 22:1777–1782.CrossRefGoogle Scholar
  34. 34.
    Nichols, C.W. and Koelle, G.B. (1967): Science 155:477–478.CrossRefGoogle Scholar
  35. 35.
    Nichols, C.W. and Koelle, G.B. (1968): J. Comp. Neurol. 133:1–16.CrossRefGoogle Scholar
  36. 36.
    Parent, A. and Butcher, L.L. (1976): J. Comp. Neurol. 170:205–226.CrossRefGoogle Scholar
  37. 37.
    Parent, A., Gravel, S. and Olivier, A. (1979): IN Advances in Neurology, Vol. 24: The Extrapyramidal System and its Disorders (eds) L.J. Poirier, T.L. Sourkes and P.J. Bedard, Raven Press, New York, pp. 1–11.Google Scholar
  38. 38.
    Rossier, J. (1975): Brain Res. 98:619–622.CrossRefGoogle Scholar
  39. 39.
    Silver, A. (1974): The Biology of Cholinesterases, North Holland/American Elsevier, New York.Google Scholar
  40. 40.
    Talbot, K., Woolf, N.J. and Butcher, L.L. (1981): Brain Res. Bull, (in press).Google Scholar
  41. 41.
    Vandermaelen, C.P., Bonduki, A.C. and Kitai, S.T. (1979): Brain Res. 175:356–361.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • L. L. Butcher
    • 1
    • 2
  • N. J. Woolf
    • 2
  • A. Albanese
    • 1
  • S. H. Butcher
    • 3
  1. 1.Department of PsychologyUniversity of CaliforniaLos AngelesUSA
  2. 2.Brain Research InstituteUniversity of CaliforniaLos AngelesUSA
  3. 3.Mental Retardation Research CenterUniversity of CaliforniaLos AngelesUSA

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