Interactions of Neuropeptides with Cholinergic Septal-Hippocampal Pathway: Indication for a Possible Trans-Synaptic Regulation
The peculiar way in which the brain processes, stores and retrieves information is determined by an interplay of biochemical and electrical mechanisms which are contained and function within complex neuronal loops. The nature of these interactions and the way in which they relate to information processing is not understood. These circuits possess intrinsic regulatory features presumably related to memory which are dependent upon feedback and extrinsic modulatory influences for their function. Modulatory processes by definition include local interneurons, afferent fibers from other brain nuclei and neuroendocrine factors. The coexistence of neuropeptides with other primary transmitters in neurons adds further flexibility to the system but reduces our ability to comprehend the neurochemical processes in defined anatomical pathways. Thus, more sensitive and specific techniques are required to study these processes. To this end we have used gas chromatography mass spectrometry (GCMS) to examine the actions of peptides on the activity of the septal hippocampal cholinergic pathway (SHCP). The assay of acetylcholine turnover (TRAch) by GCMS has been shown to be an accurate index for estimating biochemically the activity of septal cholinergic neurons (13).
KeywordsGABAergic Interneuron Primary Transmitter Local Interneuron Dopaminergic Innervation Electrical Mechanism
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