Regulation of Septal-Hippocampal Cholinergic Neurons by Catecholamines

  • S. E. Robinson
  • D. L. Cheney
  • E. Costa
Part of the Advances in Behavioral Biology book series (ABBI, volume 25)


The septum occupies a pivotal site in the brain, connecting the lower centers of the central nervous system with higher centers including the limbic areas. It is, therefore, in a position to be involved in such important processes as the organization of memory and emotional responsiveness. Of the neuronal projections from the septum a cholinergic projection from the septum to the hippocampus has been described in particular detail.


Dopaminergic Neuron Locus Coeruleus Cholinergic Neuron Medial Septum Noradrenergic Neuron 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Assaf, S.Y. and Miller, J.J. (1977): Brain Res. 129:353–360.CrossRefGoogle Scholar
  2. 2.
    Biscoe, T.J. and Straughan, D.A. (1966): J. Physiol. 183:341–359.Google Scholar
  3. 3.
    Brownstein, M., Saavedra, J.M. and Palkovits, M. (1974): Brain Res. 79:431–436.CrossRefGoogle Scholar
  4. 4.
    Brücke, F., Gogolak, G. and Stumpf, C. (1963): Pflug. Arch. Ges. Physiol. 276:456–470.CrossRefGoogle Scholar
  5. 5.
    Cheney, D.L., Trabucchi, M., Racagni, G., Wang, C. and Costa, E. (1974): Life Sci. 15:1977–1990.CrossRefGoogle Scholar
  6. 6.
    Cheney, D.L., Robinson, S.E., Malthe-Sørenssen, D., Wood, P.L., Commissiong, J.W. and Costa, E. (1978): IN Advances in Pharmacological Therapeutics, Vol. 5, Neuropsychopharmacology (ed) C. Dumont, Pergamon Press, New York, pp. 241–250.Google Scholar
  7. 7.
    Costa, E. and Groppetti, A. (1970): IN Amphetamines and Their Related Compounds (eds) E. Costa and S. Garattini, Raven Press, New York, pp. 231–255.Google Scholar
  8. 8.
    Dahlstrom, A. and Fuxe, K. (1964): Acta Physiol. Scand, Suppl. 232, 62:1–55.Google Scholar
  9. 9.
    Dudar, J.D. (1975): Brain Res. 83:123–133.CrossRefGoogle Scholar
  10. 10.
    Farley, I.J., Price, K.S., McCullough, E., Deck, J.H., Hordynski, W. and Hornykiewicz, O. (1978): Science 200:456–458.CrossRefGoogle Scholar
  11. 11.
    Gerhards, H.J., Carenzi, A. and Costa, E. (1974): N.-S. Arch. Pharmacol. 286:49–63.CrossRefGoogle Scholar
  12. 12.
    Gogolak, G., Stumpf, C.H., Petshe, H. and Sterc, J. (1968): Brain Res. 7:201–207.CrossRefGoogle Scholar
  13. 13.
    Jones, B.E. and Moore, R.Y. (1977): Brain Res. 127:23–53.CrossRefGoogle Scholar
  14. 14.
    Jones, B.E., Halaris, A.E., Mcllhany, M. and Moore, R.Y. (1977) Brain Res. 127:1–21.CrossRefGoogle Scholar
  15. 15.
    Kuhar, M.J. and Yamamura, H.I. (1976): Brain Res. 110:229–243.CrossRefGoogle Scholar
  16. 16.
    Kuhar, M.J., Sethy, V.H., Roth, R.H. and Aghajanian, G.K. (1973): J. Neurochem. 20:581–593.CrossRefGoogle Scholar
  17. 17.
    Lewis, P.R. and Shute, C.D. (1967): Brain 90:521–539.CrossRefGoogle Scholar
  18. 18.
    Lewis, P.R., Shute, C.C.D. and Silver, A. (1967): J. Physiol. 191:215–224.Google Scholar
  19. 19.
    Lindvall, O. (1975): Brain Res. 87:89–95.CrossRefGoogle Scholar
  20. 20.
    Lindvall, O and Stenevi, U. (1978): Cell. Tiss. Res. 190:383–407.CrossRefGoogle Scholar
  21. 21.
    Lowry, O.H., Roberts, N.R., Leiner, K.Y., Wu, M.L., Farr, A. L. and Albers, R.W. (1954): J Biol. Chem. 207:30–49.Google Scholar
  22. 22.
    McGeer, E.G., Wada, J.A., Terao, A. and Jung, E. (1969): Exp. Neurol. 24:277–284.CrossRefGoogle Scholar
  23. 23.
    McLennan, H. and Miller, J.J. (1974): J. Physiol. 237:625–633.Google Scholar
  24. 24.
    Mellgren, S.I. and Srebro, B. (1973): Brain Res. 52:19–36.CrossRefGoogle Scholar
  25. 25.
    Moore, R.Y. (1978): J. Comp. Neurol. 177:665–684.CrossRefGoogle Scholar
  26. 26.
    Moroni, F., Malthe-Sørenssen, D., Cheney, D.L. and Costa, E. (1978): Brain Res. 150:333–341.CrossRefGoogle Scholar
  27. 27.
    O’Donohue, T.L., Crowley, W.R. and Jacobowitz, D.M. (1979): Brain Res. 172:87–100.CrossRefGoogle Scholar
  28. 28.
    Pepeu, G., Mulas, A. and Mulas, M.L. (1973): Brain Res. 57: 153–164.CrossRefGoogle Scholar
  29. 29.
    Pickel, V.M., Segal, M. and Bloom, F.E. (1974): J. Comp. Neurol. 155:15–42.CrossRefGoogle Scholar
  30. 30.
    Racagni, G., Cheney, D.L., Trabucchi, M., Wang, C. and Costa, E. (1974): Life Sci. 15:1961–1975.CrossRefGoogle Scholar
  31. 31.
    Raisman, G. (1966): Brain 89:317–348.CrossRefGoogle Scholar
  32. 32.
    Robinson, S.E., Cheney, D.L. and Costa, E. (1978): N.-S. Arch. Pharmacol. 304:263–269.CrossRefGoogle Scholar
  33. 33.
    Robinson, S.E., Cheney, D.L. and Costa, E. (1979): IN Catecholamines: Basic and Clinical Frontiers, Vol. 2 (eds) E. Usdin, I. Kopin and J. Barchas, Pergamon Press, New York, pp. 1077–1079.Google Scholar
  34. 34.
    Robinson, S.E., Malthe-Sørenssen, D., Wood, P.L. and Commissiong, J. (1979): J. Pharmacol. Exp. Ther. 208:476–479.Google Scholar
  35. 35.
    Rommelspacher, H. and Kuhar, M.J. (1974): Brain Res. 81:243–251.CrossRefGoogle Scholar
  36. 36.
    Segal, M. (1974): Life Sci. 14:1345–1351.CrossRefGoogle Scholar
  37. 37.
    Segal, M. (1976): J. Physiol. 261:617–631.Google Scholar
  38. 38.
    Segal, M. and Landis, S.C. (1974): Brain Res. 82:263–268.CrossRefGoogle Scholar
  39. 39.
    Smith, C.M. (1974): Life Sci. 14:2159–2166.CrossRefGoogle Scholar
  40. 40.
    Speciale, S.G., Crowley, W.R., O’Donohue, T.L. and Jacobowitz, D.M. (1978): Brain Res. 154:128–133.CrossRefGoogle Scholar
  41. 41.
    Steiner, F. (1968): Pflug. Arch. 303:173–180.CrossRefGoogle Scholar
  42. 42.
    Stevens, J.R. (1973): Arch. Gen. Psychiat.:29:177–189.CrossRefGoogle Scholar
  43. 43.
    Storm-Mathisen, J. (1970): J. Neurochem. 17:739–750.CrossRefGoogle Scholar
  44. 44.
    Ungerstedt, U. (1971): Acta Physiol. Scand. Suppl. 367.Google Scholar
  45. 45.
    Young, W.S. and Kuhar, M.J. (1979): Eur. J. Pharmacol. 59: 317–319.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • S. E. Robinson
    • 2
  • D. L. Cheney
    • 1
  • E. Costa
    • 1
  1. 1.Laboratory of Preclinical PharmacologyNIMH St. Elizabeths HospitalUSA
  2. 2.Department of Medical Pharmacology and Toxicology, College of MedicineTexas A&M UniversityCollege StationUSA

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